PHASE RESPONSE CURVES FOR EXERCISE AND BRIGHT LIGHT

运动和强光的相位响应曲线

• 批准号: 6390083
• 负责人: DANIEL Frederick KRIPKE
• 金额: $ 56.75万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6390083
• 关键词: age difference; body temperature; circadian rhythms; clinical research; exercise; gender difference; human old age (65+); human subject; melatonin; photostimulus; sleep; urinalysis; young adult human (21-34)

DESCRIPTION (adapted from investigator's abstract): The investigator's laboratory has discovered an appalling prevalence of malsynchronization of circadian rhythms among volunteers averaging 70 years of age. Aging people may be abnormally resistant to the circadian synchronizing effects of bright light. If so, we may need to develop alternative methods by which older Americans can synchronize their circadian rhythms to the environment. Recent studies indicate that exercise may shift circadian rhythms in young adults, but nothing is known about the value of exercise for regulating circadian rhythms in the aging population. It seems crucial to extend our understanding of exercise effects on the circadian system and, specifically, to compare the potential values of exercise and bright light for correcting the circadian malsynchronization of older Americans. The project will establish circadian phase response curves both for exercise and for bright light in 96 volunteers, ages 18-30 plus 128 older volunteers ages 60-75 years. Volunteers will be recorded for 4.8 to 4.6 days while following an ultra-short sleep-wake cycle, consisting of 30 minutes for sleeping, followed by 60 minutes for waking. Baseline circadian phases of urinary 6-sulphatoxymelatonin, urinary free cortisol, temperature and sleep propensity will be assessed every 90 min. Oral temperature will be sampled every 30 min. Volunteers will be given experimental phase-shifting treatments (exercise or bright light) for 3 days. Resultant circadian phases will then be determined to compute the phase response curves, in order to examine interactions of stimulus (exercise vs. light), age, and gender on circadian responsiveness.

描述(改编自调查员摘要)：调查员的 实验室发现了一种令人震惊的不同步现象 平均年龄为70岁的志愿者的昼夜节律。老龄化的人可能 对强光的昼夜同步效应具有异常抵抗力。 如果是这样的话，我们可能需要开发替代方法，使美国老年人能够 使它们的昼夜节律与环境同步。最近的研究表明 这种运动可能会改变年轻人的昼夜节律，但目前尚不清楚 论运动在老年调节昼夜节律中的价值 人口。扩展我们对运动影响的理解似乎至关重要。 昼夜节律系统，具体地说，比较 运动和强光纠正人的昼夜节律不同步 年长的美国人。该项目将建立昼夜节律阶段响应曲线。 96名年龄在18-30岁外加128名志愿者的锻炼和强光锻炼 老年志愿者的年龄在60-75岁之间。志愿者人数将在4.8到4.6之间 白天，同时遵循超短的睡眠-醒来周期，由30分钟组成 睡眠时间为60分钟，清醒时间为60分钟。基线昼夜节律阶段 尿6-硫氧基角质激素、尿游离皮质醇、体温和睡眠 倾向将每隔90分钟进行一次评估。将对口腔温度进行采样 每隔30分钟。志愿者将接受实验性的相移治疗 (运动或强光)3天。由此产生的昼夜节律阶段将是 确定要计算相响应曲线，以便检查 刺激(运动与光照)、年龄和性别对昼夜节律的交互作用 响应性。