FAMILIAL SCHIZOPHRENIA SPECTRUM PERSONALITY DISORDERS

家族性精神分裂症谱系人格障碍

• 批准号: 6392032
• 负责人: GUNVANT K THAKER
• 金额: $ 22.19万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6392032
• 关键词: attention; behavior test; biomarker; clinical research; community; family genetics; genetic susceptibility; human subject; memory; neuropsychological tests; personality disorders; phenotype; problem solving; saccades; schizophrenia; smooth pursuit eye movement; verbal behavior

DESCRIPTION (Applicant's abstract): A wealth of data, including a recent linkage study, suggest that abnormalities in smooth pursuit eye movements mark the schizophrenia phenotype. Deficits in vigilance, working memory and other neurocognitive functions are frequently observed in relatives of patients with schizophrenia and are considered putative phenotypic markers. In spite of these rich data, several issues remain unclear. What is the precise neurophysiologic mechanism underlying the pursuit abnormality in schizophrenia spectrum? Are various putative liability markers correlated? Are some of the cognitive measures marking a different dimension of the phenotype (or a different phenotype)? With these questions in mind, the application broadly aims to: i) apply refined methods of evaluating smooth pursuit eye movement function to studies in relatives of patients with schizophrenia in order to understand the neurobiology of genetic vulnerability to schizophrenia; ii) to demonstrate that the refined measures of smooth pursuit identify relatives at risk (i.e., relatives with schizophrenia spectrum personalities, SSP) with high accuracy as suggested by our preliminary data; and iii) to determine the relationship among various phenotypic markers and whether they make independent contributions in identifying a phenotype. We plan to recruit four groups of subjects (1) first degree biological relatives of schizophrenic patients with (n=30) and (2) without SSP symptoms (n=30), and (3) community subjects with no known family history of psychosis with (n=30) and (4) without SSP symptoms (n=6O). We will administer a battery of eye movement and neurocognitive tests in these groups of subjects. We have a specific hypothesis regarding the nature of smooth pursuit abnormality in schizotypy. This hypothesis will be assessed using ocular motor and other cognitive (e.g., working memory) tasks. Other neurocognitive measures will be compared in these four groups. And we will explore the ability of eye tracking measures alone, cognitive measures alone and the measures in combination in accurately predicting relative status.

描述（申请人摘要）：大量数据，包括最近的 连锁研究表明，异常的顺利追求眼球运动， 标记精神分裂症的表型。 警觉性、工作记忆和 其他的神经认知功能也经常在 精神分裂症患者，被认为是假定的表型标记。 尽管有这些丰富的数据，但有几个问题仍然不清楚。 是什么 追踪异常的神经生理机制 精神分裂症谱？ 各种推定责任标记是否相关？ 一些认知测量标志着一个不同的维度， 表型（或不同的表型）？ 考虑到这些问题， 应用程序的广泛目标是：i）应用评估平滑的改进方法 追踪眼动功能对患者亲属的研究 精神分裂症，以了解遗传神经生物学 易患精神分裂症; ii）证明改进的措施 平稳追踪识别处于危险中的亲属（即，亲属 精神分裂症谱系人格，SSP）的高准确性 我们的初步数据;和iii）确定之间的关系 不同的表型标记以及它们是否独立贡献 来鉴定一个表型。 我们计划招收四组科目（1）第一学位生物学 精神分裂症患者的亲属（n=30）和（2）无SSP症状 （n=30）和（3）社区受试者，无已知的精神病家族史 有SSP症状者30例，无SSP症状者4例（n= 60）。 我们将管理一个 在这些组中进行眼动和神经认知测试， 科目 我们有一个关于光滑性质的特定假设 异型性的追求异常。 该假设将使用 眼运动和其他认知（例如，工作记忆）任务。 其他 将在这四组中比较神经认知测量。 我们会 探索眼动追踪单独测量的能力， 以及组合在一起的措施来准确地预测相对状态。