FOLLOW-UP STUDY OF OBSESSIVE COMPULSIVE DISORDER

描述：在过去的十年中，我们的 了解流行性出血热的流行病学、病因和治疗。 强迫症(OCD)。来自早期研究的数据表明， 强迫症的病程通常是慢性的。然而，在这方面存在着显著的差距 关于这一过程的长期模式和预测因素的文献 无序。我们不知道某些亚型的强迫症是否具有更大的危害性 当然不同于其他亚型。强迫症对心理社会功能的影响 时间是目前临床上另一个尚未检查的相关领域 在之前的研究中。这项提议的广泛目标是开发一种 全面描述强迫症的纵向过程和结果 400例强迫症受试者的前瞻性、纵向、观察性研究 三到五年的时间。具体目标是：全面 描述强迫症的长期病程模式；临床鉴定 有意义的缓解和复发预测指标；前瞻性地描述 接受精神治疗的数量；评估 心理社会功能、生活质量和强迫症症状严重程度 随访期。使用凯勒开发的定义明确的方法和 同事们对焦虑和抑郁进行了观察研究，这项研究将 使用DSM-IV标准对连续400名强迫症患者进行评估 在三到五年的随访期内出现精神障碍。有关以下内容的详细信息 症状状态和严重程度、功能障碍、生活质量、诊断 接受的状态和治疗将被系统地记录使用 每隔一年使用经过验证的可靠性和有效性的仪器。这 这项研究将是第一个全面的前瞻性观测研究 强迫症的病程，这将是第一项前瞻性确定的研究 根据DSM-IV标准的缓解率和复发率。它将提供 关于治疗和治疗的纵向方面的重要新信息 缓解和复发的预测指标反过来将有助于完善数据 支持强迫症中同源亚型的存在。

DESCRIPTION: There have been significant advances over the last decade in our understanding of the epidemiology, etiology, and treatment of obsessive-compulsive disorder (OCD). Data from older studies suggests that the course of OCD is usually chronic. However, there are significant gaps in the literature regarding the long-term patterns of course and predictors of this disorder. We do not know whether certain subtypes of OCD have a more pernicious course than other subtypes. The impact of OCD on psychosocial functioning over time is another currently clinically relevant area that has not been examined in previous studies. The broad objective of this proposal is to develop a comprehensive picture of the longitudinal course and outcome of OCD using a prospective, longitudinal, observational design to follow 400 subjects with OCD over a period of three to five years. Specific aims are to: comprehensively describe the long-term patterns of course of OCD; identify clinically meaningful predictors of remission and relapse; prospectively describe the amount of psychiatric treatments received; assess the relationship between psychosocial function, quality of life and OC symptom severity over the follow-up period. Using a well-defined method developed by Keller and colleagues for observational studies of anxiety and depression, the study will evaluate 400 consecutive patients with OCD using DSM-IV criteria for the disorder over a three to five year follow-up period. Detailed information on symptom status and severity, functional impairment, quality of life, diagnostic Status and treatments received will be recorded systematically using instruments with proven reliability and validity at yearly intervals. This study will be the first comprehensive prospective observational study of the course of illness in OCD and will be the first study to prospectively determine remission and relapse rates according to DSM-IV criteria. It will provide important new information about longitudinal aspects of treatment and predictors of remission and relapse that will, in turn, help refine data supporting the existence of homogeneous subtypes in OCD.