FOLLOW-UP STUDY OF OBSESSIVE COMPULSIVE DISORDER

描述：在过去的十年里，我们的研究取得了重大进展。 了解流行病学，病因学和治疗 强迫症（OCD）。早期研究的数据表明， 强迫症通常是慢性的。然而，在这方面存在着重大差距。 关于长期的课程模式和预测因素的文献 disorder.我们不知道强迫症的某些亚型是否有更有害的 与其他亚型相比。强迫症对心理社会功能的影响 时间是另一个目前尚未研究的临床相关领域 在以前的研究中。这项建议的主要目标是制定一项 使用一个全面的纵向过程和结果的强迫症 前瞻性、纵向、观察性设计，随访400例强迫症受试者 在三到五年的时间里。具体目标是： 描述强迫症病程的长期模式;临床识别 缓解和复发的有意义的预测因子;前瞻性描述 接受精神病治疗的数量;评估 心理社会功能、生活质量和OC症状严重程度 随访期。使用Keller开发的定义明确的方法， 同事进行焦虑和抑郁的观察性研究，这项研究将 使用DSM-IV标准评估400名连续的强迫症患者， 在三到五年的随访期内，详细资料说明 症状状态和严重程度、功能损害、生活质量、诊断 将使用以下工具系统记录接受的状态和治疗 每年一次的时间间隔，具有经过验证的可靠性和有效性的工具。这 这项研究将是第一个全面的前瞻性观察性研究， 强迫症的病程，并将是第一个前瞻性地确定 根据DSM-IV标准的缓解率和复发率。它将提供 关于治疗纵向方面的重要新信息， 缓解和复发的预测因子，反过来， 支持强迫症存在同质亚型。

DESCRIPTION: There have been significant advances over the last decade in our understanding of the epidemiology, etiology, and treatment of obsessive-compulsive disorder (OCD). Data from older studies suggests that the course of OCD is usually chronic. However, there are significant gaps in the literature regarding the long-term patterns of course and predictors of this disorder. We do not know whether certain subtypes of OCD have a more pernicious course than other subtypes. The impact of OCD on psychosocial functioning over time is another currently clinically relevant area that has not been examined in previous studies. The broad objective of this proposal is to develop a comprehensive picture of the longitudinal course and outcome of OCD using a prospective, longitudinal, observational design to follow 400 subjects with OCD over a period of three to five years. Specific aims are to: comprehensively describe the long-term patterns of course of OCD; identify clinically meaningful predictors of remission and relapse; prospectively describe the amount of psychiatric treatments received; assess the relationship between psychosocial function, quality of life and OC symptom severity over the follow-up period. Using a well-defined method developed by Keller and colleagues for observational studies of anxiety and depression, the study will evaluate 400 consecutive patients with OCD using DSM-IV criteria for the disorder over a three to five year follow-up period. Detailed information on symptom status and severity, functional impairment, quality of life, diagnostic Status and treatments received will be recorded systematically using instruments with proven reliability and validity at yearly intervals. This study will be the first comprehensive prospective observational study of the course of illness in OCD and will be the first study to prospectively determine remission and relapse rates according to DSM-IV criteria. It will provide important new information about longitudinal aspects of treatment and predictors of remission and relapse that will, in turn, help refine data supporting the existence of homogeneous subtypes in OCD.