Cerebellar Neural Networks and Eyeblink Conditioning

小脑神经网络和眨眼调节

• 批准号: 6325405
• 负责人: Joseph Steinmetz
• 金额: $ 30.32万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6325405
• 关键词: association learning; behavioral /social science research tag; bioimaging /biomedical imaging; brain electrical activity; brain mapping; central neural pathway /tract; cerebellar cortex; conditioning; electrophysiology; experimental brain lesion; histology; laboratory rabbit; neural information processing; neural inhibition; neural plasticity; reflex

DESCRIPTION: (Adapted from applicant's abstract): The long-term objective of this research is to advance our understanding of how the cerebellum is involved in encoding classical eyeblink conditioning, a simple, associative, motor learning procedure. Data collected to date have provided strong evidence that populations of neurons in specific regions of the cerebellar cortex and the interpositus nucleus receive convergent input concerning the stimuli used in eyeblink conditioning and change their firing patterns in a manner that is responsible for the acquisition and performance of the learned CR. While the neural network involved in encoding classical eyeblink conditioning has been worked out, there is much less known about how portions of this network interact during learning. The specific objectives of the research proposed here are to use brain recording, lesion and stimulation methods to study relationships between learning-related activity in the cerebellar cortex and learning-related activity in the interpositus nucleus. Four experiments are proposed. First, the interpositus nucleus will be either permanently lesioned with kainic acid or temporarily activated by muscimol and activity in the cerebellar cortex (lobule HVI and the anterior lobe) will be studied during acquisition and performance of eyeblink conditioning. Second, the cerebellar cortex will be either lesioned or inactivated and conditioning related activity in the interpositus nucleus will be examined. Third, double-labeling, tract-tracing techniques will be used to study the pattern of projections between cerebellar cortical areas and the deep cerebellar nuclei. Lastly, stimulation and recording techniques will be used to evaluate whether or not a "rebound from cortical inhibition" mechanism may play a role in promoting neural plasticity associated with conditioning. When completed, this research should provide important new data concerning how cerebellar neural networks are involved in motor learning procedures, and, more generally how neural systems interact to promote behavioral change. This systems-level understanding of how the brain operates during learning is crucial for the development of new treatments and therapies for a variety of pathologies that produce learning and memory deficits, including developmental influences, degenerative diseases and neural injury.

描述：（改编自申请人的摘要）：长期目标 这项研究是为了加深我们对小脑如何参与的理解 在编码经典的眨眼条件反射时，一种简单的、联想的、运动的 学习程序。迄今为止收集的数据提供了强有力的证据表明 小脑皮层特定区域的神经元群和 间核接收有关所用刺激的会聚输入 眨眼调节并以以下方式改变其发射模式 负责所学 CR 的获取和表现。虽然 参与编码经典眨眼条件反射的神经网络 解决了这个问题后，人们对于这个网络的某些部分是如何工作的知之甚少。 学习过程中互动。这里提出的研究的具体目标 就是利用大脑记录、病变和刺激的方法来研究 小脑皮层学习相关活动与 间核中与学习相关的活动。四个实验是 建议的。首先，间核将永久受损 与红藻氨酸或通过蝇蕈醇暂时激活并在 小脑皮质（小叶 HVI 和前叶）将在 眨眼调节的获取和表现。二、小脑 皮质将受到损害或失活以及调节相关活动 将检查间核。三、双重标签 束追踪技术将用于研究投影模式 小脑皮质区和小脑深部核团之间。最后， 刺激和记录技术将用于评估是否 “皮质抑制反弹”机制可能起到促进作用 与调节相关的神经可塑性。本研究完成后 应该提供有关小脑神经网络如何运作的重要新数据 参与运动学习过程，更一般地说，神经系统如何 互动以促进行为改变。这种系统级的理解是如何 大脑在学习过程中的运作对于新能力的发展至关重要 针对各种病理的治疗和疗法，产生学习和 记忆缺陷，包括发育影响、退行性疾病和 神经损伤。