TREATMENT AND OUTCOME OF EARLY ONSET BIPOLAR DISORDER

描述(改编自申请人摘要)：双相情感障碍的发病 在青春期增加了学业失败、离家安置、 吸毒上瘾，还有自杀。在青少年中，双相情感障碍 常伴有妄想、幻觉或严重的攻击性或 需要使用辅助性药物进行急性治疗的破坏性行为 除了情绪稳定剂外，还有抗精神病药物。目前还没有数据显示 什么时候应该停用抗精神病药物，或者是否完全停用。 尽管确定哪些患者可以维持治疗很重要 单独使用锂可以降低发生长期不良反应的风险，如 作为迟发性运动障碍(TD)，防止破坏性也很重要 反复发作的疾病。锂电池的故障率很高 一般的维持性治疗。对于患有精神病的青少年来说 特征或攻击性、破坏性行为，作为他们狂热的一部分，继续说 辅助抗精神病药物可能会提供额外的预防效果。 此外，使用新型抗精神病药物的TD风险较低可能会改变 风险：有利于长期抗精神病药物治疗的受益比例。

DESCRIPTION (Adapted from the Applicant's Abstract): Onset of bipolar disorder during adolescence increases the risk of school failure, out-of-home placement, drug abuse and addiction, and suicide. In adolescents, bipolar disorder is often accompanied by delusions, hallucinations, or severe assaultive or destructive behaviors that require acute treatment with adjunctive antipsychotic medication in addition to a mood stabilizer. There are no data on when to withdraw antipsychotic medication or whether to withdraw it at all. Although it is important to identify patients who could be maintained on lithium alone to decrease the risk of developing long-term adverse effects such as tardive dyskinesia (TD), it is also important to prevent disruptive recurrences of episodes of illness. There is a high rate of failure on lithium maintenance treatment in general. For adolescents who have had psychotic features or assaultive, destructive behavior as part of their mania, continued adjunctive antipsychotic medication may offer additional prophylactic efficacy. In addition, a lower risk of TD with the novel antipsychotics may alter the risk: benefit ratio in favor of longer-term antipsychotic treatment.