WHITE MATTER ABNORMALITIES IN BIPOLAR ADOLESCENTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本研究建议使用MRI、扩散张量成像(DTI)和磁共振波谱(MRS)来确定25名临床稳定的双相躁狂症或混合期青少年和25名年龄、性别和智商匹配的健康志愿者在脑白质特征上是否存在显著差异。我们假设，与健康对照组相比，双相青少年(A)更有可能出现融合的白质高信号；(B)白质束完整性降低，DTI扫描的各向异性显著降低；(C)脑白质中N-乙酰天冬氨酸(NAA)水平较低。我们还假设，与健康对照组相比，青少年双相情感障碍受试者的大脑整体发育较差，表现为：(A)广泛的皮质灰质缺陷，最明显的是前额叶区域，以及(B)侧脑室扩大。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study proposes to use MRI, Diffusion Tensor Imaging (DTI) and Magnetic Resonance Spectroscopy (MRS) to determine if there are significant differences in white matter characteristics between 25 clinically stabilized bipolar-manic or mixed phase adolescents and 25 age, gender and IQ-matched healthy volunteers. We hypothesize that, in comparison to healthy controls, bipolar adolescents (a) will be more likely to have confluent white matter hyperintensities; (b) will exhibit decreased integrity of white matter tracts as evidenced by significantly lower anisotropy on DTI scanning; and (c) will have lower N-acetyl aspartate (NAA) levels in white matter based on spectroscopy. We also hypothesize that, in comparison to healthy controls, our adolescent bipolar subjects will have poor global development of the brain as evidenced by: (a) widespread cortical gray matter deficits, most pronounced in the prefrontal area, and (b) enlarged lateral ventricles