MULTICHANNEL IMPLANTABLE SYSTEM FOR NEURAL CONTROL

用于神经控制的多通道植入系统

• 批准号: 6393479
• 负责人: Paul Hunter Peckham
• 金额: $ 60.06万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6393479
• 关键词: arm; bioengineering /biomedical engineering; biomedical equipment development; biosensor device; clinical research; electromyography; electrophysiology; electrostimulus; functional ability; hand; human subject; human therapy evaluation; implant; medical implant science; medical rehabilitation related tag; nervous system prosthesis; neuromuscular function; neuromuscular stimulator; neuroregulation; paralysis; rehabilitation; spinal cord injury; telemetry

DESCRIPTION: (adapted from Investigator's abstract) The aim of this project is to implement and evaluate an advanced neuroprosthetic system for restoration of hand-arm function in human subjects who have sustained cervical level spinal cord injury. The neuroprosthesis will provide the person with C5 tetraplegia with control of grasp and release and elbow extension by electrical stimulation of the paralyzed muscles. These functions will enable the user to regain the versatile manipulative functions which will increase their ability to perform activities of daily living independently. The myoelectric control signal which provides the command input and the stimulation that activates the muscles will be implanted surgically. Thus, the user will be free from issues of sensor mounting and maintenance of cabling and connections to the leads and electrodes on the extremities. The neuroprosthesis to be implemented consists of an external control unit, a multichannel implanted stimulator-telemeter, and implanted electrodes which sense muscle activity (a myoelectric signal). The project will result in (1) completed fabrication of all implanted and external components of the advanced neuroprosthetic system, (2) enhancement of the outcome assessment techniques used to measure system performance, and (3) evaluation of its efficacy in five individuals. Outcome evaluations will measure the function of individual components of the neuroprosthesis and the performance of users in grasp-release tests and activities of daily living. These tests allow statistical comparisons of the user's abilities before surgery with those achieved after surgery, both with the neuroprosthesis turned on and turned off. The results of this project will demonstrate the feasibility of a totally implanted neuroprosthesis and the significant improvements in hand function achieved through its use. The long term objectives of this research are to provide innovative techniques for restoration of functional movement in persons with central nervous system disorders. This research will develop the fundamental modules of neuroprosthetic systems for restoration of control of movement and sensation and perform clinical research to demonstrate their feasibility. The proposed system also has application in the efforts to provide standing and walking in thoracic level spinal cord injury, stroke, and head injury. These types of applications have been considered in defining the proposed system, so that it will be versatile across different clinical applications.

描述：（改编自研究者摘要）本项目的目的是 实施和评估一种先进的神经假体系统， 持续颈段脊髓损伤的人类受试者的手臂功能 脊髓损伤神经假体将为C5四肢瘫痪的人提供 通过电刺激控制抓握和释放以及肘伸展 麻痹的肌肉。这些功能将使用户能够重新获得 多功能的操作功能，这将提高他们的能力， 独立的日常生活活动。肌电控制信号 提供命令输入和刺激，激活肌肉将 通过手术植入体内因此，用户将免于传感器的问题 导线和电极的布线和连接的安装和维护 在四肢上。要实施的神经假体由一个 外部控制单元，多通道植入式刺激遥测仪，以及 植入电极，感知肌肉活动（肌电信号）。 该项目将导致（1）完成所有植入和 先进的神经假体系统的外部组件，（2）增强 用于测量系统性能的结果评估技术，以及（3） 在五个人中评估其功效。成果评价将 测量神经假体各个组件的功能， 用户在抓握-释放测试和日常生活活动中的表现。 这些测试允许对用户的能力进行统计比较， 手术与手术后获得的那些，都与神经假体转向 打开和关闭。该项目的结果将证明可行性 完全植入的神经假体和手部的显著改善 通过使用实现的功能。 这项研究的长期目标是提供创新技术 用于恢复中枢神经系统患者的功能性运动 紊乱这项研究将开发的基本模块， 用于恢复运动和感觉控制的神经修复系统 并进行临床研究以证明其可行性。 拟议的系统还可应用于提供站立和 在胸段脊髓损伤、中风和头部损伤中行走。这些 在界定拟议系统时，已考虑到各类应用， 它将在不同的临床应用中通用。