Combining synthesis and industrial biotechnology for high-throughput biomaterials functionalisation

结合合成和工业生物技术实现高通量生物材料功能化

• 批准号: 1782371
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1782371
• 关键词: Combining; synthesis; industrial; biotechnology; throughput

The UK's aging population needs cheaper biomedical materials with improved performance. However, new robust chemical and biotechnological processes for surface functionalization are urgently needed to create these biomaterials. This project is an exciting opportunity to bring together the latest developments in chemical synthesis and enzymatic catalysis, creating new technologies that will allow the creation of advanced functionalized biomaterials for applications in healthcare. Building upon our ongoing work, high-throughput methods for the glycosylation of nanostructured biomaterials, such as liposomes (for drug delivery), cell culture scaffolds (for regenerative medicine) and wound dressings (for chronic wounds) will be investigated. Beyond the fundamental science that will be discovered during these studies, this new methodology will enable manufacturers to create tailored high-quality products for different healthcare markets.

英国的老龄化人口需要更便宜的生物医学材料和更好的性能。然而，迫切需要新的强大的化学和生物技术的表面功能化过程来创建这些生物材料。该项目是一个令人兴奋的机会，汇集了化学合成和酶催化的最新发展，创造了新技术，将允许创建用于医疗保健应用的先进功能化生物材料。在我们正在进行的工作的基础上，将研究用于纳米结构生物材料，如脂质体（用于药物递送），细胞培养支架（用于再生医学）和伤口敷料（用于慢性伤口）的糖基化的高通量方法。除了在这些研究中发现的基础科学之外，这种新方法将使制造商能够为不同的医疗保健市场创造量身定制的高质量产品。

项目成果

High-throughput chemical and chemoenzymatic approaches to saccharide-coated magnetic nanoparticles for MRI.

• DOI: 10.1039/c9na00376b
• 发表时间: 2019-09-11
• 期刊: NANOSCALE ADVANCES
• 影响因子: 4.7
• 作者: Fallows, Thomas W.;McGrath, Andrew J.;Silva, Joana;McAdams, Simon G.;Marchesi, Andrea;Tuna, Floriana;Flitsch, Sabine L.;Tilley, Richard D.;Webb, Simon J.
• 通讯作者: Webb, Simon J.