MOTOR CORTEX AND THALAMOCORTICAL NETWORK IN LOCOMOTION

运动中的运动皮层和丘脑皮质网络

• 批准号: 6394264
• 负责人: IRINA N BELOOZEROVA
• 金额: $ 13.19万
• 依托单位: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-05 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6394264
• 关键词: behavior test; behavioral /social science research tag; brain electrical activity; cats; cell type; chordate locomotion; electromyography; experimental brain lesion; gait; interneurons; microelectrodes; motor cortex; neural information processing; performance; proprioception /kinesthesia; psychomotor function; statistics /biometry; thalamocortical tract; thalamus

DESCRIPTION (adapted from applicant's abstract) This proposal is aimed at 1) understanding the relationship between identified elements within the motor cortical network and locomotion behavior, and 2) understanding the mechanisms governing thalamo-cortical relations in the intact, functioning motor system. All data will be obtained from cats trained to walk inside an experimental chamber on a flat surface at different speeds, uphill and downhill, with weights attached to forelimbs, overcoming obstacles and walking on flat cross-pieces of a horizontal ladder. The relationship of identified cortico-cortical neurons, corticofugal efferent neurons and putative interneurons will be recorded during different locomotion behaviors. In addition, the activity of these identified neurons will be recorded simultaneously with the activity of thalamo-cortical projection neurons, and interactions among them will be analyzed using cross correlation methods at " rest" and during locomotion. Special emphasis will be placed on elucidating rules governing the strength and specificity of functional connections among the population of thalamo-cortical and cortical neurons under study. Two major issues will be addressed: 1) To what extent does the activity of different classes of identified motor cortex efferent neurons (e.g., S1, SII, collosal, corticothalamic, corticospinal, etc) and putative inhibitory interneurons differ in relation to locomotion under different conditions? Are properties better associated with cortical layer, morphological cell type or the destination of the axon? 2) What are the activity patterns of VL thalamo-cortical projection neurons during locomotion under different conditions and how do these patterns compare with those of cortical neurons? What are the characteristics of the synaptic linkages between VL projection neurons and cortical recipient neurons and how do these linkages change under different conditions of locomotion?

描述（改编自申请人的摘要） 该提案的目的是 1) 理解所识别的之间的关系 运动皮质网络和运动行为中的元素，以及 2) 了解丘脑-皮质关系的调节机制 完整、功能正常的运动系统。所有数据均来自受过训练的猫 以不同的速度在平坦的表面上行走在实验室内， 上坡和下坡，前肢附有重物，克服障碍 并在水平梯子的平坦横梁上行走。的关系 识别出皮质-皮质神经元、皮质传出神经元和假定的 中间神经元将在不同的运动行为期间被记录。在 此外，这些识别出的神经元的活动将被记录 与丘脑皮质投射神经元的活动同时发生，并且 将使用互相关方法来分析它们之间的相互作用“ 休息”和运动过程中。将特别强调阐明 管理之间功能联系的强度和特异性的规则 正在研究的丘脑皮质和皮质神经元群体。两大 将解决以下问题：1）不同的活动在多大程度上 已识别的运动皮层传出神经元的类别（例如，S1、SII、大体、 皮质丘脑、皮质脊髓等）和假定的抑制性中间神经元 不同条件下的运动有何不同？是否有属性 与皮质层、形态细胞类型或 轴突的目的地？ 2) VL的活动模式是什么 丘脑皮质投射神经元在不同运动条件下的运动过程 这些模式与皮质神经元的模式相比如何？ VL投射之间的突触联系有何特点 神经元和皮质受体神经元以及这些联系在 不同的运动条件？