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MOTOR CORTEX AND THALAMOCORTICAL NETWORK IN LOCOMOTION

运动中的运动皮层和丘脑皮质网络

基本信息

批准号：
6529579
负责人：
IRINA N BELOOZEROVA
金额：
$ 13.59万
依托单位：
ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-07-05 至 2004-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (adapted from applicant's abstract) This proposal is aimed at 1) understanding the relationship between identified elements within the motor cortical network and locomotion behavior, and 2) understanding the mechanisms governing thalamo-cortical relations in the intact, functioning motor system. All data will be obtained from cats trained to walk inside an experimental chamber on a flat surface at different speeds, uphill and downhill, with weights attached to forelimbs, overcoming obstacles and walking on flat cross-pieces of a horizontal ladder. The relationship of identified cortico-cortical neurons, corticofugal efferent neurons and putative interneurons will be recorded during different locomotion behaviors. In addition, the activity of these identified neurons will be recorded simultaneously with the activity of thalamo-cortical projection neurons, and interactions among them will be analyzed using cross correlation methods at " rest" and during locomotion. Special emphasis will be placed on elucidating rules governing the strength and specificity of functional connections among the population of thalamo-cortical and cortical neurons under study. Two major issues will be addressed: 1) To what extent does the activity of different classes of identified motor cortex efferent neurons (e.g., S1, SII, collosal, corticothalamic, corticospinal, etc) and putative inhibitory interneurons differ in relation to locomotion under different conditions? Are properties better associated with cortical layer, morphological cell type or the destination of the axon? 2) What are the activity patterns of VL thalamo-cortical projection neurons during locomotion under different conditions and how do these patterns compare with those of cortical neurons? What are the characteristics of the synaptic linkages between VL projection neurons and cortical recipient neurons and how do these linkages change under different conditions of locomotion?

描述（改编自申请人的摘要）该提案的目的是 1) 理解所识别的之间的关系运动皮质网络和运动行为中的元素，以及 2) 了解丘脑-皮质关系的调节机制完整、功能正常的运动系统。所有数据均来自受过训练的猫以不同的速度在平坦的表面上行走在实验室内，上坡和下坡，前肢附有重物，克服障碍并在水平梯子的平坦横梁上行走。的关系识别出皮质-皮质神经元、皮质传出神经元和假定的中间神经元将在不同的运动行为期间被记录。在此外，这些识别出的神经元的活动将被记录与丘脑皮质投射神经元的活动同时发生，并且将使用互相关方法来分析它们之间的相互作用“ 休息”和运动过程中。将特别强调阐明管理之间功能联系的强度和特异性的规则正在研究的丘脑皮质和皮质神经元群体。两大将解决以下问题：1）不同的活动在多大程度上已识别的运动皮层传出神经元的类别（例如，S1、SII、大体、皮质丘脑、皮质脊髓等）和假定的抑制性中间神经元不同条件下的运动有何不同？是否有属性与皮质层、形态细胞类型或轴突的目的地？ 2) VL的活动模式是什么丘脑皮质投射神经元在不同运动条件下的运动过程这些模式与皮质神经元的模式相比如何？ VL投射之间的突触联系有何特点神经元和皮质受体神经元以及这些联系在不同的运动条件？

项目成果

期刊论文数量（21）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Contribution of different limb controllers to modulation of motor cortex neurons during locomotion.

DOI：
10.1523/jneurosci.6511-10.2011
发表时间：
2011-03-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Zelenin PV;Deliagina TG;Orlovsky GN;Karayannidou A;Dasgupta NM;Sirota MG;Beloozerova IN
通讯作者：
Beloozerova IN

Role of GABA A inhibition in modulation of pyramidal tract neuron activity during postural corrections.

GABA A 抑制在姿势矫正过程中锥体束神经元活动调节中的作用。

DOI：
10.1111/j.1460-9568.2007.05413.x
发表时间：
2007
期刊：
The European journal of neuroscience
影响因子：
0
作者：
Tamarova,ZinaidaA;Sirota,MikhailG;Orlovsky,GrigoriN;Deliagina,TatianaG;Beloozerova,IrinaN
通讯作者：
Beloozerova,IrinaN

Distinct Thalamo-Cortical Controls for Shoulder, Elbow, and Wrist during Locomotion.