Immunity to multiple pathogens: identification of a fungal immune receptor in barley to ascomycete and basidiomycete fungi

大多数植物对自然界中存在的大多数病原体具有抗性。相反，它是允许病原体生命周期完成的少数相互作用。非宿主对大多数病原体的抗性倾向表明植物具有抵抗各种病原体的实质性能力和/或病原体必须做出关键的适应才能在植物物种上增殖。我们已经确定了一个抗性基因座，条件抗子囊菌和担子菌真菌Magnaporthe和Puccinia striiformis f。白藓这两种病原体对全球小麦和水稻生产造成重大影响，并且相同的免疫受体调节多种病原体识别的可能性在植物病理学中具有深远的意义。该项目将通过图位克隆、关联遗传学和生物信息学的结合来分离真菌免疫受体。

The majority of plants are resistant to the majority of pathogens that exist in nature. In contrast, it is the minority of interactions that permit lifecycle completion of the pathogen. The proclivity of nonhost resistance to the majority of pathogens suggests plants have a substantial capacity to resist various pathogens and/or that pathogens must make crucial adaptations to proliferate on a plant species. We have identified a resistance locus that conditions resistance to the ascomycete and basidiomycete fungi Magnaporthe oryzae and Puccinia striiformis f. sp. tritici. These two pathogens cause significant impact on global wheat and rice production, and the possibility that the same immune receptor conditions multiple pathogen recognition has profound implications in plant pathology. The project will involve the isolation of the fungal immune receptor through a combination of map-based cloning, association genetics, and bioinformatics.