Conference on Frontiers of Structural Biology

描述（由申请人提供）： 结构生物学家正在破译生物学的机制， 大分子以惊人的速度。 X射线晶体学提供了 复杂分子组件的原子分辨率结构，例如 核糖体和RNA聚合酶，其大小是无法想象的， 不久前。 核磁共振光谱学让我们不仅能探测 结构，还有动力学，越来越大的蛋白质分子， 溶液和膜中的核酸。 这些丰富的结构 信息的补充是戏剧性的改进，在计算 生物大分子的结构和动力学分析。 的 所有这些新信息的整合需要跨学科的 利用广泛的生物化学和生物物理工具， 探索分子功能，同时保留生物学上重要的问题， 在舞台中央 拟议的基石会议将汇集结构性的 对这些问题感兴趣的生物学家，这对 基础生物学和药物发现的过程。

DESCRIPTION (Provided by applicant): Structural biologists are deciphering the mechanisms of biological macromolecules at a breathtaking pace. X-ray crystallography has provided atomic resolution structures of complex molecular assemblies, such as the ribosome and RNA polymerase, of sizes that would have been unimaginable just a short time ago. NMR spectroscopy is allowing us to probe not just the structure, but also the dynamics, of ever larger molecules of proteins and nucleic acids in solution and in membranes. This wealth of structural information is complemented by dramatic improvements in the computational analysis of the structure and dynamics of biological macromolecules. The integration of all this new information requires an inter-disciplinary approach that utilizes a wide range of biochemical and biophysical tools to probe molecular function, while keeping the biologically important questions at center stage. The proposed Keystone Meeting will bring together structural biologists interested in these issues, which have deep implications both for fundamental biology and for the process of drug discovery.