Conference on Frontiers of Structural Biology
Conference on Frontiers of Structural Biology
批准号:
6446615
负责人:
JOHN KURIYAN
金额:
$0.45万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2001
资助国家:
美国
项目状态:
已结题
起止时间:
2001-09-01 至 2002-08-31
中文摘要
描述(由申请人提供):
结构生物学家正在破译生物的机制
大分子以惊人的速度。X射线结晶学提供了
复杂分子组件的原子分辨结构,如
核糖体和RNA聚合酶,其大小是无法想象的
不久前。核磁共振光谱学使我们不仅可以探测
结构,但也是动力学,越来越大的蛋白质分子和
溶液和膜中的核酸。这一丰富的结构
信息的补充是在计算方面的显著改进
分析生物大分子的结构和动力学。这个
整合所有这些新信息需要跨学科的
一种利用广泛的生化和生物物理工具
探索分子功能,同时保留生物学上的重要问题
在舞台中央。拟议的Keystone会议将把结构性的
对这些问题感兴趣的生物学家,这些问题对
基础生物学和药物发现过程。
英文摘要
DESCRIPTION (Provided by applicant):
Structural biologists are deciphering the mechanisms of biological
macromolecules at a breathtaking pace. X-ray crystallography has provided
atomic resolution structures of complex molecular assemblies, such as the
ribosome and RNA polymerase, of sizes that would have been unimaginable just a
short time ago. NMR spectroscopy is allowing us to probe not just the
structure, but also the dynamics, of ever larger molecules of proteins and
nucleic acids in solution and in membranes. This wealth of structural
information is complemented by dramatic improvements in the computational
analysis of the structure and dynamics of biological macromolecules. The
integration of all this new information requires an inter-disciplinary
approach that utilizes a wide range of biochemical and biophysical tools to
probe molecular function, while keeping the biologically important questions
at center stage. The proposed Keystone Meeting will bring together structural
biologists interested in these issues, which have deep implications both for
fundamental biology and for the process of drug discovery.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Mechanism and Evolutionary Design of DNA Polymerase Clamp Loaders.
-
批准号:10587243
-
项目类别:
-
资助金额:$33.71万
-
财政年份:2023
-
负责人:JOHN KURIYAN
-
依托单位:
Evolution of proximal kinase network in T cells
-
批准号:10428138
-
项目类别:
-
资助金额:$41.1万
-
财政年份:2011
-
负责人:JOHN KURIYAN
-
依托单位:
Evolution of proximal kinase network in T cells
-
批准号:10615817
-
项目类别:
-
资助金额:$40.07万
-
财政年份:2011
-
负责人:JOHN KURIYAN
-
依托单位:
STRUCTURAL STUDIES OF CALCIUM/CALMODULIN DEPENDENT KINASE II AND E COLI REPLICA
-
批准号:7598158
-
项目类别:
-
资助金额:$0.02万
-
财政年份:2007
-
负责人:JOHN KURIYAN
-
依托单位:
STRUCTURAL STUDIES OF CALCIUM/CALMODULIN DEPENDENT KINASE II AND E COLI REPLICA
-
批准号:7370608
-
项目类别:
-
资助金额:$0.09万
-
财政年份:2006
-
负责人:JOHN KURIYAN
-
依托单位:
CRYSTALLOGRAPHIC STUDIES OF DNA REPLICATION & CELLULAR SIGNALING: ONCOGENE
-
批准号:6667808
-
项目类别:
-
资助金额:$14.27万
-
财政年份:2002
-
负责人:JOHN KURIYAN
-
依托单位:
CRYSTALLOGRAPHIC STUDIES OF DNA REPLICATION & CELLULAR SIGNALING: ONCOGENE
-
批准号:6491131
-
项目类别:
-
资助金额:$14.27万
-
财政年份:2001
-
负责人:JOHN KURIYAN
-
依托单位:
STRUCTURAL STUDIES OF DNA POLYMERASE PROCESSIVITY CLAMP LOADERS
-
批准号:6483499
-
项目类别:
-
资助金额:$12.06万
-
财政年份:2001
-
负责人:JOHN KURIYAN
-
依托单位:--
CRYSTALLOGRAPHIC STUDIES OF DNA REPLICATION & CELLULAR SIGNALING: ONCOGENE
-
批准号:6339143
-
项目类别:
-
资助金额:$6.49万
-
财政年份:2000
-
负责人:JOHN KURIYAN
-
依托单位:
STRUCTURAL STUDIES OF DNA POLYMERASE PROCESSIVITY CLAMP LOADERS
-
批准号:6339323
-
项目类别:
-
资助金额:$1.37万
-
财政年份:2000
-
负责人:JOHN KURIYAN
-
依托单位:--
X-RAY CRYSTALLOGRAPHIC OF SIGNAL TRANSDUCTION PATHWAYS: FK506-BINDING PROTEIN
-
批准号:6307521
-
项目类别:
-
资助金额:$0.82万
-
财政年份:1999
-
负责人:JOHN KURIYAN
-
依托单位:
STRUCTURAL STUDIES OF DNA POLYMERASE PROCESSIVITY CLAMP LOADERS
-
批准号:6315703
-
项目类别:
-
资助金额:$1.37万
-
财政年份:1999
-
负责人:JOHN KURIYAN
-
依托单位:--
CRYSTALLOGRAPHIC STUDIES OF DNA REPLICATION & CELLULAR SIGNALING: ONCOGENE
-
批准号:6220503
-
项目类别:
-
资助金额:$6.49万
-
财政年份:1999
-
负责人:JOHN KURIYAN
-
依托单位:
XRAY CRYSTAL & BIOCHEMICAL STUDIES OF SIGNAL TRANSDUCTION PATHWAYS INV FK506
-
批准号:6118288
-
项目类别:
-
资助金额:$0.09万
-
财政年份:1998
-
负责人:JOHN KURIYAN
-
依托单位:
CRYSTAL STRUCTURE OF TYROSINE PHOSPHORYLATED STAT 1 DIMER BOUND TO DNA
-
批准号:6281280
-
项目类别:
-
资助金额:$5.96万
-
财政年份:1998
-
负责人:JOHN KURIYAN
-
依托单位:
CRYSTAL STRUCTURE OF TYROSINE PHOSPHORYLATED STAT 1 DIMER BOUND TO DNA
-
批准号:6120507
-
项目类别:
-
资助金额:$0.02万
-
财政年份:1998
-
负责人:JOHN KURIYAN
-
依托单位:
CRYSTALLOGRAPHIC STUDIES OF MOLECULAR SIGNALING: HIV
-
批准号:6251637
-
项目类别:
-
资助金额:$1.12万
-
财政年份:1997
-
负责人:JOHN KURIYAN
-
依托单位:
X-RAY CRYSTALLOGRAPHIC OF SIGNAL TRANSDUCTION PATHWAYS: FK506-BINDING PROTEIN
-
批准号:6279548
-
项目类别:
-
资助金额:$0.17万
-
财政年份:1997
-
负责人:JOHN KURIYAN
-
依托单位:
CHARACTERIZATION OF CELL EXPRESSED RECOMBINANT PROTEINS
-
批准号:6249489
-
项目类别:
-
资助金额:$1.24万
-
财政年份:1996
-
负责人:JOHN KURIYAN
-
依托单位:
CRYSTAL STRUCTURE OF DNA POLYMERASE III ALPHA CHAIN
-
批准号:6249447
-
项目类别:
-
资助金额:$1.24万
-
财政年份:1996
-
负责人:JOHN KURIYAN
-
依托单位: