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CRYSTAL STRUCTURE OF TYROSINE PHOSPHORYLATED STAT 1 DIMER BOUND TO DNA

CRYSTAL STRUCTURE OF TYROSINE PHOSPHORYLATED STAT 1 DIMER BOUND TO DNA
与 DNA 结合的酪氨酸磷酸化 STAT 1 二聚体的晶体结构
批准号：
6281280
负责人：
JOHN KURIYAN
金额：
$5.96万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-15 至 1999-08-14
来源：
https://reporter.nih.gov/project-details/6281280
关键词：
biological products biomedical resource proteins radiography structural biology

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英文摘要
The crystal structure of the DNA complex of a STAT-1 homodimer has been determined at 2.9  resolution. STAT-1 utilizes a DNA binding domain with an immunoglobulin fold, similar to that of NFkB and the p53 tumor suppressor protein. The STAT-1 dimer forms a contiguous C-shaped clamp around DNA that is stabilized by reciprocal and highly specific interactions between the SH2 domain of one monomer and the C-terminal segment, phosphorylated on tyrosine, of the other. The phosphotyrosine binding site of the SH2 domain in each monomer is coupled structurally to the DNA binding domain, suggesting a potential role for the SH2-phosphotyrosine interaction in the stabilization of DNA interacting elements.
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Mechanism and Evolutionary Design of DNA Polymerase Clamp Loaders.
  • 批准号：
    10587243
  • 项目类别：
  • 资助金额：
    $33.71万
  • 财政年份：
    2023
  • 负责人：
    JOHN KURIYAN
  • 依托单位：
    VANDERBILT UNIVERSITY
Evolution of proximal kinase network in T cells
Evolution of proximal kinase network in T cells
STRUCTURAL STUDIES OF CALCIUM/CALMODULIN DEPENDENT KINASE II AND E COLI REPLICA
  • 批准号：
    7598158
  • 项目类别：
  • 资助金额：
    $0.02万
  • 财政年份：
    2007
  • 负责人：
    JOHN KURIYAN
  • 依托单位：
    STANFORD UNIVERSITY
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