Conference: Second Messengers & Protein Phosphorylation

描述（由申请人提供）： 戈登研究会议（GRC）第二届信使与蛋白质会议 磷酸化将于2001年6月10日至6月15日在Kimball Union举行 学院，新罕布什尔州。本申请寻求部分支持， 会议的运作。在信号转导领域的研究是一个 这是研究细胞如何调节生长的重要部分， 分化和细胞死亡。在过去的一年里， 激酶、磷酸酶和G蛋白偶联酶的研究进展 信号系统这些进展包括许多信号的新X射线结构 组件以及功能研究定义的要素内的信号 瀑布此外，我们对离子是如何产生的知识也有了爆炸性的增长。 通道被调节，磷酸化事件和 利用细胞骨架结构控制和调节分子信号 事件会议的目的是整合生物化学，结构， 细胞生物学和基因组学方法， 了解信号传导机制的分子方面。像其他 GRC，本次会议将从申请中选出135名参与者，包括 来自工业界和学术界的代表。与会者将包括高级 科学家、博士后和研究生。活动不断 将来自不同学科的新研究人员注入信号 转换领域和2001年会议将是一个重要的“培训” 为这些新的调查人员。会议将由9名 每届会议有一名讨论负责人和四至六名发言者， 最近作出重要贡献的调查人员和提交的 摘要。这将有助于确保年轻调查人员、妇女和 少数民族作为主要参与者。此外，两个海报会议将 有组织的。我们选择了两位主讲人：亚历山大瓦尔沙夫斯基，选择 由于泛蛋白和泛蛋白样蛋白的作用越来越大， 调节信号转导途径的修饰，以及Alfred Gilman， 已经开始努力组建G蛋白信号转导联盟。这 代表了一种新的科学方法，他将报告 联盟和战略，这使得信号转导社区， 与联盟互动。必须指出的是， 信使和蛋白质磷酸化会议跨越了许多 美国国立卫生研究院内的研究所，包括糖尿病，癌症，普通医学 科学、儿童健康和发展以及免疫学，仅举几例 几个.

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) Conference on Second Messengers & Protein Phosphorylation will be held from June 10 to June 15, 2001 in Kimball Union Academy, New Hampshire. This application seeks partial support for the operation of the conference. Research in the area of signal transduction is an essential part of the investigation into how cells regulate growth, differentiation and cell death. Within the past year there have been many advances in our understanding of kinase, phosphatase and G-protein coupled signaling system. These advances include new X-ray structures for many signal components as well as functional studies defining elements within signaling cascades. In addition, there has been an explosion in our knowledge of how ion channels are modulated, the inter-connections of phosphorylation events and the use of cytoskeletal architecture to control and regulate molecular signaling events. The purpose of the meeting is to integrate biochemical, structural, cell biological and genomic approaches into providing a comprehensive understanding of the molecular aspects of signaling mechanisms. Like other GRCs, this meeting will select 135 participants from applications including representatives from industry and academia. Participants will include senior scientists, postdoctoral fellows and graduate students. There is a constant infusion of new researchers from various disciplines into the signal transduction area and the 2001 conference will be an important "training" ground for these new investigators. The conference will consist of nine sessions, each with a discussion leader and four to six speakers, selected from investigators who have made important recent contributions and from submitted abstracts. This will help to insure inclusion of young investigators, women and minorities as primal participants. Additionally two poster sessions will be organized. We have selected two keynote speakers: Alexander Varshavsky, chosen because of the increasing role of ubiquitin and ubiquantin-like protein modification in regulating signal transduction pathways, and Alfred Gilman, who has initiated efforts to form a G-protein signal transduction Alliance. This represents a new way of doing science and he will report on the progress of the Alliance and the strategies, which allow the signal transduction community to interact with the Alliance. It is important to point out that the Second Messengers and Protein Phosphorylation meeting cuts across many of the Institutes within the NIH, including Diabetes, Cancer, General Medical Sciences, Child Health and Development, as well as Immunology, to mention only a few.