Conference: Second Messengers & Protein Phosphorylation

描述(由申请人提供)： 戈登研究会议(GRC)关于第二信使和蛋白质的会议 磷酸化将于2001年6月10日至6月15日在金博尔联合公司举行 学院，新汉普郡。此应用程序寻求对 会议的运作。信号转导领域的研究是一种 这是研究细胞如何调节生长的重要部分， 分化和细胞死亡。在过去的一年里，有很多 我们对激酶、磷酸酶和G蛋白偶联的认识进展 信令系统。这些进展包括用于许多信号的新的X射线结构 组件以及定义信令中的元素的功能研究 瀑布。此外，我们对离子如何产生的了解也出现了爆炸性增长。 通道是被调制的，磷酸化事件和 利用细胞骨架结构控制和调节分子信号 事件。会议的目的是将生化、结构、 细胞生物学和基因组学方法提供全面的 了解信号机制的分子方面。像其他人一样 GRCS，本次会议将从以下申请中挑选135名与会者 来自工业界和学术界的代表。参与者将包括高年级学生 科学家、博士后研究员和研究生。有一个常量 将不同学科的新研究人员注入到信号中 换能器领域和2001年会议将是一次重要的“训练” 为这些新的调查人员做准备。会议将由九个人组成。 会议，每个会议有一名讨论负责人和四到六名发言者，选自 最近做出重要贡献和提交的调查人员 摘要。这将有助于确保纳入年轻的调查人员、妇女和 少数族裔作为主要参与者。此外，还将举行两次海报会议 有条理的。我们选出了两位主讲人：亚历山大·瓦尔沙夫斯基 由于泛素和泛量素样蛋白的作用越来越大 调节信号转导通路的修改，以及阿尔弗雷德·吉尔曼，他 发起了组建G蛋白信号转导联盟的努力。这 代表了一种新的科学工作方式，他将报告 联盟和策略，允许信号转导社区 与联盟互动。必须指出的是，第二个 信使和蛋白质磷酸化会议跨越了许多 美国国立卫生研究院内的研究所，包括糖尿病、癌症、普通医学 科学、儿童健康和发展以及免疫学，仅此一提 几个。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) Conference on Second Messengers & Protein Phosphorylation will be held from June 10 to June 15, 2001 in Kimball Union Academy, New Hampshire. This application seeks partial support for the operation of the conference. Research in the area of signal transduction is an essential part of the investigation into how cells regulate growth, differentiation and cell death. Within the past year there have been many advances in our understanding of kinase, phosphatase and G-protein coupled signaling system. These advances include new X-ray structures for many signal components as well as functional studies defining elements within signaling cascades. In addition, there has been an explosion in our knowledge of how ion channels are modulated, the inter-connections of phosphorylation events and the use of cytoskeletal architecture to control and regulate molecular signaling events. The purpose of the meeting is to integrate biochemical, structural, cell biological and genomic approaches into providing a comprehensive understanding of the molecular aspects of signaling mechanisms. Like other GRCs, this meeting will select 135 participants from applications including representatives from industry and academia. Participants will include senior scientists, postdoctoral fellows and graduate students. There is a constant infusion of new researchers from various disciplines into the signal transduction area and the 2001 conference will be an important "training" ground for these new investigators. The conference will consist of nine sessions, each with a discussion leader and four to six speakers, selected from investigators who have made important recent contributions and from submitted abstracts. This will help to insure inclusion of young investigators, women and minorities as primal participants. Additionally two poster sessions will be organized. We have selected two keynote speakers: Alexander Varshavsky, chosen because of the increasing role of ubiquitin and ubiquantin-like protein modification in regulating signal transduction pathways, and Alfred Gilman, who has initiated efforts to form a G-protein signal transduction Alliance. This represents a new way of doing science and he will report on the progress of the Alliance and the strategies, which allow the signal transduction community to interact with the Alliance. It is important to point out that the Second Messengers and Protein Phosphorylation meeting cuts across many of the Institutes within the NIH, including Diabetes, Cancer, General Medical Sciences, Child Health and Development, as well as Immunology, to mention only a few.