Investigating tyrosine phosphorylation of Notch proteins

研究 Notch 蛋白的酪氨酸磷酸化

基本信息

  • 批准号:
    10578301
  • 负责人:
  • 金额:
    $ 40.83万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-03-01 至 2026-02-28
  • 项目状态:
    未结题

项目摘要

Project Summary Extracellular matrix, integrins, and Notch collectively regulate a host of normal and pathological cellular activities. Evidence emerging from our preliminary studies shows that these cellular entities are coordinated into a signaling mechanism that has not been previously observed. The implications of our observation are broad and likely to have deep impacts on our understanding of cell interactions within cellular microenvironments as well as cellular behaviors in a range of normal and pathological scenarios. In this renewal application, we investigate the hypothesis that Notch tyrosine phosphorylation regulates angiogenesis. To address this hypothesis, we have proposed two aims that dig deeper into the molecular regulation of Notch activity through tyrosine phosphorylation by Src kinase, and to understand how Notch tyrosine phosphorylation impacts angiogenesis and vascular function. Throughout these studies and in the spirit of the AREA program, we will engage high school, undergraduate, and graduate students to build scientific confidence and teach skills these students will require in order to pursue careers in science. At the conclusion of our studies, we will have accomplished two important milestones towards understanding this novel regulatory mechanism. Specifically, we will have unraveled many molecular details describing how Src controls Notch, and we will have defined the importance of this signaling cascade to vascular biology. Since both Notch and vascular biology operate in a wide variety of normal and disease states, our work is highly relevant to the promotion of human health.
项目总结

项目成果

期刊论文数量(0)
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Allan R Albig其他文献

Allan R Albig的其他文献

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{{ truncateString('Allan R Albig', 18)}}的其他基金

Investigation of a potential MGP negative feedback loop mediated by BMP, Notch,
研究由 BMP、Notch、介导的潜在 MGP 负反馈回路
  • 批准号:
    8653273
  • 财政年份:
    2014
  • 资助金额:
    $ 40.83万
  • 项目类别:
Identification and Characterization of an Integrin - Notch Signaling Axis
整合素 -Notch 信号轴的鉴定和表征
  • 批准号:
    9231986
  • 财政年份:
    2012
  • 资助金额:
    $ 40.83万
  • 项目类别:
Identification and Characterization of a Integrin - Notch signaling Axis
整合素 - Notch 信号轴的鉴定和表征
  • 批准号:
    8367287
  • 财政年份:
    2012
  • 资助金额:
    $ 40.83万
  • 项目类别:
Mechanisms by which MAGP-2 Promotes Angiogenesis
MAGP-2 促进血管生成的机制
  • 批准号:
    8065215
  • 财政年份:
    2009
  • 资助金额:
    $ 40.83万
  • 项目类别:
Mechanisms by which MAGP-2 Promotes Angiogenesis
MAGP-2 促进血管生成的机制
  • 批准号:
    7811528
  • 财政年份:
    2009
  • 资助金额:
    $ 40.83万
  • 项目类别:
Identification of TGF-B regulated angiogenesis genes
TGF-B调节的血管生成基因的鉴定
  • 批准号:
    6918524
  • 财政年份:
    2003
  • 资助金额:
    $ 40.83万
  • 项目类别:
Identification of TGF-B regulated angiogenesis genes
TGF-B调节的血管生成基因的鉴定
  • 批准号:
    6793984
  • 财政年份:
    2003
  • 资助金额:
    $ 40.83万
  • 项目类别:
Identification of TGF-B regulated angiogenesis genes
TGF-B调节的血管生成基因的鉴定
  • 批准号:
    6694872
  • 财政年份:
    2003
  • 资助金额:
    $ 40.83万
  • 项目类别:

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