CONFERENCE ON B CELL IMMUNOBIOLOGY AND DISEASE

产品说明： （摘自申请人摘要）这一多学科 会议将及时更新B细胞生物学的进展， 与正常的生物过程和疾病状态有关。 B淋巴细胞 作为免疫应答的关键介质和作为人类免疫应答的靶点， 疾病我们对分子生物学的理解已经取得了关键性的进展， 调节B细胞发育和活化。最近的进展也是 在定义负责重组的分子机制时， 导致功能性抗体基因形成和调节的事件 这些事件。 B细胞，像T细胞一样，经历选择性机制， 决定生存和功能能力。需要适当的监管 以确保保护性免疫反应，但避免自身免疫。 信号通过 B细胞受体和调节辅助受体已被证明是主要 发育和活化B细胞命运的决定因素。至关重要 以确定这些信号如何与其他途径整合， 免疫力与耐受力 新的见解应该来自对 B细胞与T细胞、基质细胞和各种类型的 树突状细胞 关键转录调控异常的机制 导致B细胞恶性肿瘤的因子和信号分子也正在被 探索;这些知识将导致新的治疗机会， 白血病和淋巴瘤。这次会议的目标是整合这些进展 在调节B细胞发育、信号转导和对 提供了一个B细胞功能和命运的分子理解， 和疾病 它将汇集成熟和年轻的调查人员， 来自基础科学和临床的博士后研究员和学生 积极讨论该领域的进展并提出新的想法 和未来实验的假设。

DESCRIPTION: (Adapted from Applicant's Abstract) This multidisciplinary conference will provide a timely update on advances in B cell biology as they relate to both normal biological processes and disease states. B lymphocytes serve as both critical mediators of immune responses and as targets of human disease. Key advances have been made in our understanding of the molecular regulation of B cell development and activation. Recent progress has also been made in defining the molecular mechanisms responsible for the recombination events leading to formation of functional antibody genes and the regulation of these events. B cells, like T cells, undergo selective mechanisms that determine both survival and functional capacity. Proper regulation is required to ensure protective immune responses but avoid autoimmunity. Signals through the B cell receptor and regulatory coreceptors have been shown to be major determinants of the fate of developing and activated B cells. It is critical to determine how such signals integrate with other pathways to determine immunity versus tolerance. New insights should come from studies of the interaction of B cells with T cells, stromal cells and various types of dendritic cells. The mechanisms by which dysregulation of key transcription factors and signaling molecules lead to B cell malignancy are also being explored; such knowledge will lead to new opportunities for therapy of leukemia and lymphoma. The goal of this meeting is to integrate these advances in regulation of B cell development, signal transduction and responsiveness to provide a molecular understanding of B cell function and fate in both health and disease. It will bring together established and younger investigators, postdoctoral fellows and students from both basic science and clinical backgrounds to actively discuss progress in the field and to provoke new ideas and hypotheses for future experimentation.