CONFERENCE ON B CELL IMMUNOBIOLOGY AND DISEASE

描述：(改编自申请者摘要)这项多学科 会议将及时提供B细胞生物学进展的最新情况，因为它们 与正常的生物过程和疾病状态有关。B淋巴细胞 既是免疫反应的关键介质，也是人类免疫反应的靶标 疾病。我们对分子的理解已经取得了重大进展。 调节B细胞的发育和激活。最近的进展也是 在定义负责重组的分子机制时提出的 导致功能性抗体基因形成和调节的事件 这些事件。B细胞，就像T细胞一样，经历选择性机制， 既要确定生存能力，又要确定功能能力。需要适当的监管 以确保保护性免疫反应，但避免自身免疫。信号通过 B细胞受体和调节辅助受体已被证明是主要的 发育和激活的B细胞命运的决定因素。这是至关重要的 以确定这些信号如何与其他途径相结合以确定 免疫力与耐受性。新的见解应该来自对 B细胞与T细胞、基质细胞及不同类型T细胞的相互作用 树突状细胞。关键转录调控失调的机制 导致B细胞恶性的因素和信号分子也正在 探索；这样的知识将带来治疗的新机会 白血病和淋巴瘤。本次会议的目标是整合这些进展 在调节B细胞发育、信号转导和对 提供对B细胞功能和命运在两种健康中的分子理解 和疾病。它将汇集老牌和年轻的调查人员， 博士后研究员和基础科学和临床学生 积极讨论这一领域的进展并激发新想法的背景 以及未来实验的假设。

DESCRIPTION: (Adapted from Applicant's Abstract) This multidisciplinary conference will provide a timely update on advances in B cell biology as they relate to both normal biological processes and disease states. B lymphocytes serve as both critical mediators of immune responses and as targets of human disease. Key advances have been made in our understanding of the molecular regulation of B cell development and activation. Recent progress has also been made in defining the molecular mechanisms responsible for the recombination events leading to formation of functional antibody genes and the regulation of these events. B cells, like T cells, undergo selective mechanisms that determine both survival and functional capacity. Proper regulation is required to ensure protective immune responses but avoid autoimmunity. Signals through the B cell receptor and regulatory coreceptors have been shown to be major determinants of the fate of developing and activated B cells. It is critical to determine how such signals integrate with other pathways to determine immunity versus tolerance. New insights should come from studies of the interaction of B cells with T cells, stromal cells and various types of dendritic cells. The mechanisms by which dysregulation of key transcription factors and signaling molecules lead to B cell malignancy are also being explored; such knowledge will lead to new opportunities for therapy of leukemia and lymphoma. The goal of this meeting is to integrate these advances in regulation of B cell development, signal transduction and responsiveness to provide a molecular understanding of B cell function and fate in both health and disease. It will bring together established and younger investigators, postdoctoral fellows and students from both basic science and clinical backgrounds to actively discuss progress in the field and to provoke new ideas and hypotheses for future experimentation.