CONFERENCE ON CHEMOKINES AND CHEMOKINE RECEPTORS

趋化因子和趋化因子受体会议

• 批准号: 6232906
• 负责人: GREGORY J LAROSA
• 金额: $ 0.6万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-15 至 2002-02-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6232906
• 关键词: chemokine; cytokine receptors; meeting /conference /symposium; travel

DESCRIPTION: (Adapted from Applicant's Abstract) The 2001 Keystone Symposium on Chemokines and Chemokine Receptors will be a timely and multidisciplinary conference designed to bring together a large group of both leading, established scientists and younger, emerging scientists, to present and discuss a wide array of topics regarding chemokine biology. Chemokines are members of a growing superfamily of proteins whose primary function is to control leukocyte trafficking through lymphoid organs and other tissues. Experimental evidence has linked chemokines and their receptors with a variety of acute and chronic inflammatory settings, allergic disease, HIV and other infectious disease, and cancer. Recently, disease model studies using either genetically modified animals, or treatment with chemokine or receptor blocking agents, have provided in vivo proof of the pathogenetic role played by some chemokines in disease, thereby validating chemokines and their receptors as pharmacological targets. Finally, chemokine receptors have also been found on a number of nonhematopoietic cells. Critical problems in the field include: difficulty in discovering small molecule chemokine inhibitors, indicating an incomplete understanding of chemokine ligand-receptor interactions; gaps in connecting chemokine receptor activation with the molecular machinery of cell migration; and an unclear vision of the physiology of chemokines in non- hematopoietic cells. This meeting will bring together scientists working on the molecular basis of chemokine responses with those working at the organismal level on problems of disease and the immune response. The goal is to stimulate new approaches to critical problems in chemokine research that may ultimately result in chemokine-directed therapeutics.

描述：（改编自申请人的摘要）2001年基石研讨会 趋化因子和趋化因子受体将是一个及时的和多学科的 会议旨在汇集一大批领导， 成熟的科学家和年轻的，新兴的科学家，提出和 讨论关于趋化因子生物学的广泛主题。趋化因子是 蛋白质超家族的成员，其主要功能是 控制白细胞通过淋巴器官和其他组织的运输。 实验证据表明，趋化因子及其受体与多种 急性和慢性炎症环境，过敏性疾病，艾滋病毒和其他 传染病和癌症。最近，疾病模型研究使用 转基因动物，或用趋化因子或受体阻断剂治疗 的致病作用提供了体内证据， 疾病中的趋化因子，从而验证趋化因子及其受体， 药理学目标。最后，还发现了趋化因子受体， 一些非造血细胞。 这一领域的关键问题包括： 发现小分子趋化因子抑制剂的困难，表明 对趋化因子配体-受体相互作用的不完全理解; 将趋化因子受体激活与细胞的分子机制联系起来 迁移;以及对非肿瘤组织中趋化因子的生理学的不清楚的看法。 造血细胞 这次会议将汇集科学家， 趋化因子反应的分子基础， 在疾病和免疫反应的问题上。目标是 刺激新的方法来解决趋化因子研究中的关键问题， 可能最终导致趋化因子导向的治疗。