VARIAN ASSOCIATES UNITY INOVA NMR SPECTROMETER CONSOLE

VARIAN ASSOCIATES UNITY INOVA 核磁共振波谱仪控制台

• 批准号: 6052319
• 负责人: James Alvin Balschi
• 金额: $ 34.5万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6052319
• 关键词: biomedical equipment purchase; magnetic resonance imaging; nuclear magnetic resonance spectroscopy

The objective of this application is to upgrade the GE Omega NMR spectrometer of the NMR Laboratory for Physiological Chemistry with a Varian Associates UNITY INOVA. Specifically, the upgrade will replace all elements of the existing system (console, probes, room temperature shims, etc.) except for the magnet. The magnet will, however, be refurbished (de-energized, seals replaced, re-energized, field mapped, and supercon shimmed). The NMR Laboratory for Physiological Chemistry in the Cardiology Division of the Department of Medicine at Brigham and Women's Hospital currently supports ten NIH funded projects. These NIH projects are based at a number of institutions: the Brigham and Women's Hospital, the Beth Israel Deaconess Medical Center, and the Boston University School of Medicine. The NIH projects supported by the NMR Laboratory for Physiological Chemistry are primarily studying the isolated perfused mouse and rat heart. Other biological systems studied include intact rat and mouse leg, isolated cells, and extract samples. The rationale for upgrading the GE Omega NMR spectrometer, which is now ten years old, is to provide significant new capabilities to the supported projects and to provide a more reliable and available resource for the user community. The scientific aims of the current NIH funded projects demand a level of system performance that can not be met by the current system. This is especially evident in the studies of the isolated perfused mouse heart where the signal to noise and time resolution available in 31P NMR experiments is not adequate. The Varian UNITY INOVA console will have much improved signal to noise performance. Current noise figures for Varian system are at least 2 dB below those of GE Omega when it was new. In addition, ten years of hard use have degraded the performance of many critical components, in particular, the probes. Replacement of these old probes will also increase signal to noise. A second concern is the reliability of the GE Omega. Many critical components of the GE Omega system are no longer available. When breakdowns occur, parts must be sent out for repair or refurbishment. This is resulting in increasingly long periods of time when the instrument is unavailable for all studies. The great demand for instrument time and the time critical nature of many project studies (e.g., transgenic animals of a specific stage of development and exoerimenta1 models of hypertrophy) makes random and lengthy periods of unavailability very expensive and disruptive. The Varian UNITY INOVA will have vastly improved reliability and constant, predictable availability.

该应用程序的目的是将核磁共振实验室用于生理化学的GE Omega核磁共振谱仪升级为Varian Associates Unity INOVA。具体来说，升级将取代现有系统的所有部件(控制台、探头、室温垫片等)。除了那块磁铁。然而，磁铁将被翻新(关闭电源，更换密封件，重新供电，绘制磁场图，并对超级粒子进行垫片)。布里格姆妇女医院医学部心脏病科的核磁共振生理化学实验室目前支持NIH资助的10个项目。美国国立卫生研究院的这些项目涉及以下几个机构：布里格姆妇女医院、贝丝以色列女执事医疗中心和波士顿大学医学院。由核磁共振生理化学实验室支持的NIH项目主要研究分离的灌流小鼠和大鼠心脏。其他研究的生物系统包括完整的大鼠和小鼠腿、分离的细胞和提取的样本。升级GE Omega核磁共振谱仪的基本原理是为所支持的项目提供重要的新功能，并为用户社区提供更可靠和可用的资源。目前NIH资助的项目的科学目标要求达到当前系统无法满足的系统性能水平。这一点在对分离的灌流小鼠心脏的研究中尤其明显，在31P核磁共振实验中可用的信号噪声比和时间分辨率是不够的。在瓦里安单位INOVA控制台将有更好的信噪比性能。目前瓦里安系统的噪声系数比GE Omega新系统时至少低2分贝。此外，十年的艰苦使用已经降低了许多关键部件的性能，特别是探头。更换这些旧探头也会增加信噪比。第二个担忧是通用电气欧米茄的可靠性。GE Omega系统的许多关键组件不再可用。当发生故障时，部件必须送去维修或翻新。这导致仪器不能用于所有研究的时间越来越长。仪器时间的巨大需求和许多项目研究的时间紧迫性(例如，特定发育阶段的转基因动物和肥大的外部模型)使得随机和长期无法获得的时间非常昂贵和破坏性。瓦里安统一INOVA将极大地提高可靠性和持续的、可预测的可用性。