ACQUISITION OF A WIDE-BORE 500 MHZ MAGNET & CONSOLE

获取宽孔 500 MHz 磁铁

• 批准号: 6053574
• 负责人: GARY Peter DROBNY
• 金额: $ 49.92万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6053574
• 关键词: biomedical equipment purchase; nuclear magnetic resonance spectroscopy

In order to apply homonuclear solid NMR dipolar recoupling experiments to magnetically dilute samples of surface-adsorbed biopolymers and high molecular acids and nucleic acid-protein complexes, we propose acquiring a wide-bore 11.75 Tesla Magnet, 2 high power amplifiers, and two triple channel CPMAS probes for use with an existing home-build solid state NMR console. At the present time, a large number of projects that require the study of magnetically dilute samples by REDOR and DRAWS at variable temperature, must be performed on a single 9.4 T wide bore magnet or on a 4.75 T wide bore magnet. Practical consideration involved in the design and construction of multi-resonant solid state NMR CPMAS probes with VT capability prevent the use of 52 mm bore magnets. At a cost of less than $500,000, half what an identical spectrometer would cost if acquired as a single package from a commercial vendor, a new solid state wide bore spectrometer will be made available to the Drobny, Stayton, and Sigurdsson research groups.

为了应用homomorphous固体NMR偶极再耦合实验磁稀释样品的表面吸附的生物聚合物和高分子酸和核酸-蛋白质复合物，我们建议收购一个宽口径11.75特斯拉磁铁，2个高功率放大器，和两个三通道CPMAS探头与现有的自制固态NMR控制台使用。目前，需要在可变温度下通过REDOR和DRAWS研究磁稀释样品的大量项目必须在单个9.4 T宽孔磁体或4.75 T宽孔磁体上进行。在设计和构造具有VT能力的多共振固态NMR CPMAS探针时，实际考虑因素阻止使用52 mm孔磁体。一个新的固态宽口径光谱仪将提供给Drobny、Stayton和Sigurdsson研究小组，其成本不到50万美元，是从商业供应商那里购买一个相同光谱仪的一半。