ACQUISITION OF A WIDE-BORE 500 MHZ MAGNET & CONSOLE

为了将同核固体核磁共振偶极再耦合实验应用于表面吸附的生物聚合物和高分子酸以及核酸-蛋白质复合体的磁稀释样品，我们建议购买一个大口径11.75特斯拉磁铁、两个高功率放大器和两个三通道CPMAS探针，用于现有的自制固态核磁共振控制台。目前，需要研究磁化稀化样品的大量工程必须在9.4T宽孔磁体上进行，或者在4.75T宽孔磁体上进行。在设计和建造具有VT能力的多谐振固态核磁共振CPMAS探头时涉及的实际考虑因素避免了使用52 mm口径的磁铁。Drobny、Stayton和Sigurdsson研究小组将以不到50万美元的成本，将Drobny、Stayton和Sigurdsson研究小组获得的新固态大口径光谱仪提供给Drobny、Stayton和Sigurdsson研究小组。

In order to apply homonuclear solid NMR dipolar recoupling experiments to magnetically dilute samples of surface-adsorbed biopolymers and high molecular acids and nucleic acid-protein complexes, we propose acquiring a wide-bore 11.75 Tesla Magnet, 2 high power amplifiers, and two triple channel CPMAS probes for use with an existing home-build solid state NMR console. At the present time, a large number of projects that require the study of magnetically dilute samples by REDOR and DRAWS at variable temperature, must be performed on a single 9.4 T wide bore magnet or on a 4.75 T wide bore magnet. Practical consideration involved in the design and construction of multi-resonant solid state NMR CPMAS probes with VT capability prevent the use of 52 mm bore magnets. At a cost of less than $500,000, half what an identical spectrometer would cost if acquired as a single package from a commercial vendor, a new solid state wide bore spectrometer will be made available to the Drobny, Stayton, and Sigurdsson research groups.