ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITY
ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITY
批准号:
6363702
负责人:
David P Crews
金额:
$17.82万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-03-10 至 2003-02-28
关键词:
behavior test behavioral /social science research tag behavioral genetics densitometry environment ethology hormone regulation /control mechanism in situ hybridization lizards mature animal neural plasticity neuroanatomy neuroendocrine system neuroregulation organ culture polymerase chain reaction radioimmunoassay sex behavior sex determination sex differentiation social behavior statistics /biometry steroid hormone steroid hormone receptor temperature vertebrate embryology
中文摘要
描述(改编自申请人摘要):本研究涉及
是什么决定了行为的变化 许多
环境变量可以对表型产生可预测的影响。 一
许多爬行动物卵的孵化温度就是这样的变量。 在
在豹纹壁虎中,胚胎变成雄性或雌性取决于它们的
发展过程中的温度。 此外,两性之间以及
性别内的差异归因于孵化温度已经
在形态学、类固醇激素的分泌和敏感性中发现,
社会性行为,生殖成功,以及神经解剖学和
调节社会性行为的大脑区域的代谢活动。 这些
环境效应类似于子宫内
哺乳动物,包括人类。 假设
内分泌系统和神经系统,重要的是,
确定是否同源机制是这些类似作用的基础,
行为 如果环境影响行为的机制
豹壁虎是保守的(即,通过性类固醇),这项研究将
为性别分化的进化提供了新的见解,
温度依赖的性别决定被认为是进化的
基因型性别决定的前体(存在于鸟类和哺乳动物中),
因为爬行动物是鸟类和哺乳动物的祖先。 如果
机制不同(即,直接温度效应),这项研究
将阐明一种新的性别分化过程,
存在于鸟类和哺乳动物中,但由于恒温,被掩盖了。 这
后一种可能性尤其重要,因为幼鸟和哺乳动物
不能像成年人那样调节体温。 拟议研究
大致可分为三类:体温调节及其关系
社会性行为(即,神经基质
介导体温调节和社会性行为重叠),
这些大脑区域和激素的神经表型的发展
环境,以及发育过程中激素调节的影响,
成年期对体温调节和社会性行为的神经操纵
行为。 最后一类实验特别重要,
它将辨别孵化温度的影响是直接的还是
间接的
英文摘要
DESCRIPTION (Adapted from applicant's abstract): This research addresses
the fundamental question of what determines behavioral variation. Many
environmental variables can produce predictable effects on phenotype. One
such variable is the incubation temperature of eggs in many reptiles. In
the leopard gecko, embryos become male or female depending upon their
temperature during development. In addition, between-sex as well as
within-sex differences attributable to incubation temperature have been
found in morphology, secretion of and sensitivity to steroid hormones,
sociosexual behavior, reproductive success, and in the neuroanatomy and
metabolic activity of brain areas that mediate sociosexual behaviors. These
environmental effects are analogous to the effect of intrauterine
environment in mammals, including humans. Given the homology of the
endocrine and nervous systems across vertebrates, it is important to
determine if homologous mechanisms underlie these analogous effects on
behavior. If the mechanism underlying environmental effects on behavior in
the leopard gecko is conserved (i.e., via sex steroids), this research will
lend new insight into the evolution of sexual differentiation because
temperature-dependent sex determination is thought to be the evolutionary
precursor to genotypic sex determination (present in birds and mammals) and
because reptiles are the ancestors of both birds and mammals. If the
mechanism is different (i.e., direct temperature effects), this research
would elucidate a novel process of sexual differentiation that may also be
present in birds and mammals but, because of homeothermy, is masked. This
latter possibility is especially important because young birds and mammals
cannot regulate their body temperature as do adults. The proposed research
is broadly categorized into three groups: thermoregulation and its relation
to sociosexual behaviors (i.e., the degree to which the neural substrates
mediating thermoregulatory and sociosexual behavior overlap), the
development of the neural phenotypes of these brain regions and hormone
milieus, and the effects of hormonal manipulations during development and
neural manipulations in adulthood on thermoregulatory and sociosexual
behaviors. The final category of experiments is particularly important as
it will discern whether the incubation temperature effects are direct or
indirect.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Ancestral Exposures/Modern Responses to EDCs
-
批准号:8595128
-
项目类别:
-
资助金额:$38.02万
-
财政年份:2013
-
负责人:David P Crews
-
依托单位:
Ancestral Exposures/Modern Responses to EDCs
-
批准号:8898800
-
项目类别:
-
资助金额:$38.03万
-
财政年份:2013
-
负责人:David P Crews
-
依托单位:
Ancestral Exposures/Modern Responses to EDCs
-
批准号:9117556
-
项目类别:
-
资助金额:$38.03万
-
财政年份:2013
-
负责人:David P Crews
-
依托单位:
Ancestral Exposures/Modern Responses to EDCs
-
批准号:8728234
-
项目类别:
-
资助金额:$37.65万
-
财政年份:2013
-
负责人:David P Crews
-
依托单位:
Ancestral Exposures/Modern Responses to EDCs
-
批准号:9321838
-
项目类别:
-
资助金额:$38.03万
-
财政年份:2013
-
负责人:David P Crews
-
依托单位:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
-
批准号:8205524
-
项目类别:
-
资助金额:$37.56万
-
财政年份:2011
-
负责人:David P Crews
-
依托单位:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
-
批准号:8475402
-
项目类别:
-
资助金额:$35.97万
-
财政年份:2011
-
负责人:David P Crews
-
依托单位:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
-
批准号:8843433
-
项目类别:
-
资助金额:$39.48万
-
财政年份:2011
-
负责人:David P Crews
-
依托单位:
Sexually dimorphic effects of endocrine disruptors on brain and behavior
-
批准号:9565756
-
项目类别:
-
资助金额:$29.7万
-
财政年份:2011
-
负责人:David P Crews
-
依托单位:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
-
批准号:8663703
-
项目类别:
-
资助金额:$35.65万
-
财政年份:2011
-
负责人:David P Crews
-
依托单位:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
-
批准号:8330794
-
项目类别:
-
资助金额:$35.86万
-
财政年份:2011
-
负责人:David P Crews
-
依托单位:
Interaction of Epigenetic and Stress Effects on Brain and Behavior
-
批准号:7828222
-
项目类别:
-
资助金额:$17.86万
-
财政年份:2009
-
负责人:David P Crews
-
依托单位:
Interaction of Epigenetic and Stress Effects on Brain and Behavior
-
批准号:7643018
-
项目类别:
-
资助金额:$21.79万
-
财政年份:2009
-
负责人:David P Crews
-
依托单位:
Epigenetic Influences on Brain and Behavior
-
批准号:6791409
-
项目类别:
-
资助金额:$11.7万
-
财政年份:2003
-
负责人:David P Crews
-
依托单位:
Epigenetic Influences on Brain and Behavior
-
批准号:6668133
-
项目类别:
-
资助金额:$14.2万
-
财政年份:2003
-
负责人:David P Crews
-
依托单位:
ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITY
-
批准号:6165210
-
项目类别:
-
资助金额:$17.44万
-
财政年份:1998
-
负责人:David P Crews
-
依托单位:
ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITY
-
批准号:6530876
-
项目类别:
-
资助金额:$18.21万
-
财政年份:1998
-
负责人:David P Crews
-
依托单位:
ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITY
-
批准号:2452077
-
项目类别:
-
资助金额:$11.99万
-
财政年份:1998
-
负责人:David P Crews
-
依托单位:
ENVIRONMENTAL INFLUENCES ON BRAIN PLASTICITY
-
批准号:2883455
-
项目类别:
-
资助金额:$17.07万
-
财政年份:1998
-
负责人:David P Crews
-
依托单位:
ENVIRONMENTAL SEX DETERMINATION AND DIFFERENTIATION
-
批准号:3325895
-
项目类别:
-
资助金额:$13.05万
-
财政年份:1989
-
负责人:David P Crews
-
依托单位: