Ancestral Exposures/Modern Responses to EDCs

祖先的接触/现代对 EDC 的反应

基本信息

  • 批准号:
    9321838
  • 负责人:
  • 金额:
    $ 38.03万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-09-01 至 2020-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The world is contaminated, never to return to conditions that existed prior to the chemical revolution. Although some local remediation of contamination has occurred, at a global level this is simply not possible. A class of contaminants is known as Endocrine Disrupting Chemicals (EDC) because of their ability to perturb the body's hormone systems. Poor storage, spills, deliberate and accidental dispersal have had well-document effects on wildlife and human health. However, the field of EDC research remains highly controversial and polarized. Such compounds are now a permanent part of our environment and creating previously unknown evolutionary pressures. We must transcend traditional toxicological testing to develop new methods and perspectives if we are to anticipate and understand EDCs' impact on the future. Life in this new world is a combination of ancestral exposures due to heritable epigenetic modifications to DNA in germ cells (transgenerational), together with exposures experienced during the individual's own lifetime (body burden) that cause molecular epigenetic changes to that individual. These processes are an underappreciated force in driving evolutionary change in all species, including humans. The challenge is how to model the cumulative and progressive changes both across lifespans and within generations. We propose a unique study of multigenerational exposures to sequential environmental toxicants, each known to perturb hormones, brain and behavior. Our proposed model investigates interactions of ancestral and immediate epigenetic modifications, factors that have never been studied together. Over the course of 6 generations, we make the iconoclastic prediction that individuals will evolve in unique ways due to contemporary environmental driving forces (chemical contamination), with descendants responding differently to proximal chemical stimuli than their ancestors. To do this work, we propose to model two exposures separated by 3 generations; different EDC classes will be used at environmentally relevant levels, each with a different mode of action. Endpoints will be body weight, physiological parameters, neurobiological gene expression and molecular epigenetic assays, together with behavioral characterization of the animals in a suite of behaviors involved in social, anxiety, and cognitive function. Realistically simulating the nature of life challenges across and within generations will provide the framework for understanding and anticipating how environmental contamination will affect the evolution of all species.
描述(申请人提供):世界被污染,永远不会回到化学革命之前存在的条件。虽然已经对污染进行了一些局部补救,但在全球层面上,这根本是不可能的。一类污染物被称为内分泌干扰化学品(EDC),因为它们能够扰乱人体的激素系统。储存不良、泄漏、故意和意外扩散对野生动物和人类健康的影响有据可查。然而,EDC的研究领域仍然存在很大的争议和两极分化。这些化合物现在是我们环境中永久的一部分,并创造了以前未知的进化压力。如果我们要预测和了解EDCs对未来的影响,我们必须超越传统的毒理学测试,开发新的方法和视角。这个新世界中的生命是由于生殖细胞中DNA的可遗传表观遗传修饰而导致的祖先暴露的组合(跨代),以及在个体自身一生中经历的导致该个体的分子表观遗传变化的暴露(身体负担)。在推动包括人类在内的所有物种的进化变化方面,这些过程是一种被低估的力量。挑战是如何对跨越生命周期和世代之间的累积和渐进变化进行建模。我们提出了一项关于连续几代人接触环境毒物的独特研究,每种毒物都会扰乱荷尔蒙、大脑和行为。我们提出的模型研究了祖先和即刻表观遗传修饰的相互作用,这些因素从未被一起研究过。在六代人的过程中,我们做出了颠覆传统的预测,即由于当代环境驱动力(化学污染),个体将以独特的方式进化,后代对近端化学刺激的反应与他们的祖先不同。为了做这项工作,我们建议对被三代分开的两种暴露建立模型;不同的EDC类别将在与环境相关的水平上使用,每一种类别都有不同的行动模式。终点是体重、生理参数、神经生物学基因表达和分子表观遗传学分析,以及动物在一系列涉及社交、焦虑和认知功能的行为中的行为特征。现实地模拟跨代和跨代人生活挑战的本质将 为理解和预测环境污染将如何影响所有物种的进化提供框架。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Transgenerational effects of polychlorinated biphenyls: 1. Development and physiology across 3 generations of rats.
Mate choice, sexual selection, and endocrine-disrupting chemicals.
  • DOI:
    10.1016/j.yhbeh.2017.09.001
  • 发表时间:
    2018-05
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Gore AC;Holley AM;Crews D
  • 通讯作者:
    Crews D
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

David P Crews其他文献

David P Crews的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('David P Crews', 18)}}的其他基金

Ancestral Exposures/Modern Responses to EDCs
祖先的接触/现代对 EDC 的反应
  • 批准号:
    8595128
  • 财政年份:
    2013
  • 资助金额:
    $ 38.03万
  • 项目类别:
Ancestral Exposures/Modern Responses to EDCs
祖先的接触/现代对 EDC 的反应
  • 批准号:
    8898800
  • 财政年份:
    2013
  • 资助金额:
    $ 38.03万
  • 项目类别:
Ancestral Exposures/Modern Responses to EDCs
祖先的接触/现代对 EDC 的反应
  • 批准号:
    9117556
  • 财政年份:
    2013
  • 资助金额:
    $ 38.03万
  • 项目类别:
Ancestral Exposures/Modern Responses to EDCs
祖先的接触/现代对 EDC 的反应
  • 批准号:
    8728234
  • 财政年份:
    2013
  • 资助金额:
    $ 38.03万
  • 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
内分泌干​​扰物对大脑的性别二态性影响
  • 批准号:
    8205524
  • 财政年份:
    2011
  • 资助金额:
    $ 38.03万
  • 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
内分泌干​​扰物对大脑的性别二态性影响
  • 批准号:
    8475402
  • 财政年份:
    2011
  • 资助金额:
    $ 38.03万
  • 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
内分泌干​​扰物对大脑的性别二态性影响
  • 批准号:
    8843433
  • 财政年份:
    2011
  • 资助金额:
    $ 38.03万
  • 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain and behavior
内分泌干​​扰物对大脑和行为的性别二态性影响
  • 批准号:
    9565756
  • 财政年份:
    2011
  • 资助金额:
    $ 38.03万
  • 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
内分泌干​​扰物对大脑的性别二态性影响
  • 批准号:
    8663703
  • 财政年份:
    2011
  • 资助金额:
    $ 38.03万
  • 项目类别:
Sexually dimorphic effects of endocrine disruptors on brain & behavior
内分泌干​​扰物对大脑的性别二态性影响
  • 批准号:
    8330794
  • 财政年份:
    2011
  • 资助金额:
    $ 38.03万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 38.03万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了