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A Novel Surface Modification Method for Dental Implants

一种新型的牙种植体表面修饰方法

基本信息

批准号：
6403358
负责人：
Rajiv Kumar Satsangi
金额：
$ 13.06万
依托单位：
RANN RESEARCH CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
起止时间：
2001-09-07 至 2003-03-01
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6403358
关键词：
apatites biomaterial development /preparation biomimetics cell adhesion cell differentiation cell proliferation dental implants hydroxyapatites medical implant science method development osteoblasts surface coating surface property titanium tooth surface

项目摘要

DESCRIPTION: The purpose of this Phase 1 application is to evaluate the applicability of a novel surface modification method of titanium Dental implant surfaces to biomimetically induce thin biological apatite formation, and thereby enhancing osteoblast response. Coatings on the titanium Dental implants will be synthesized, characterized and tested in vitro using an osteoblast progenitor cell line. Osteoblast responses will be evaluated by measuring the effects of the coatings on cell proliferation, adhesion, and differentiation. Data obtained from this study will contribute to the development of an alternative coating for optimum bone response. The rationale for using such coatings is that although HA are beneficial for initial osseointegration, thinner HA coatings have been reported to have greater interfacial bond strengths than thicker coatings. In short, the novel surface modification in this application will contribute to the development of ideal coating properties for Dental implants with biomimetically formed thin apatite layer that will have superior coating-substrate interfacial strength compared to the currently available plasma-sprayed HA-coated implants and will reduce implant failures which are costly to patients in implant cost, surgery cost, trauma and time. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：此第一阶段应用程序的目的是评估钛牙种植体新型表面改性方法的适用性仿生表面诱导薄生物磷灰石形成，以及从而增强成骨细胞反应。钛牙科种植体上的涂层将使用成骨细胞在体外合成、表征和测试祖细胞系。成骨细胞反应将通过测量涂层对细胞增殖、粘附和分化的影响。从这项研究中获得的数据将有助于开发替代涂层可实现最佳骨反应。使用此类的理由涂层的优点是虽然 HA 有利于初始骨整合，据报道，较薄的 HA 涂层具有更好的界面结合力强度优于较厚的涂层。简而言之，新颖的表面改性该应用将有助于开发理想的涂层性能用于具有仿生形成的薄磷灰石层的牙科植入物与目前的涂层相比具有优异的涂层-基材界面强度可用等离子喷涂 HA 涂层种植体，并将减少种植体失败对于患者来说，植入成本、手术成本、创伤和时间都是昂贵的。拟议的商业应用：不可用