ENTRAPMENT OF 02 IN A SEMI-SOLID FOR HYPOXIC WOUNDS

将 02 包埋在半固体中以治疗缺氧伤口

• 批准号: 6310229
• 负责人: BRUCE L GIBBINS
• 金额: $ 12.03万
• 依托单位: ACRYMED, INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-20 至 2001-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6310229
• 关键词: biomaterial development /preparation; drug delivery systems; hypoxia; oxygen; oxygen therapy; oxygen transport; polyacrylate; topical drug application; wound healing

DESCRIPTION (Verbatim from the Applicant's Abstract): More than 15 million patients in the US alone suffer from recalcitrant non-healing wounds with an estimated expenditure of greater than $10 billion in treatment costs. The demographic shift in longevity will mean an increase in the population base that is at risk of suffering from chronic non-healing wounds. There is a great need for improved methods of treating chronic wounds to promote better wound healing. Although the relationships contributing to recalcitrant wounds are complex, it is well recognized that a strong correlation between low oxygen tension and the chronic non-healing state exists. Clinical interventions directed towards increasing tissue reperfusion and tissue oxygenation have been rewarded with significant improvements in the healing of chronic wounds. However achieving improvements in tissue oxygenation involves costly surgery or special complex equipment for the delivery of hyperbaric oxygen. The specific aim of this study is to evaluate the feasibility of developing a material that will deliver O2 in a sustained release fashion into the wound environment. This study aims to evaluate the utilization of chemistry that generates the formation of oxygen-containing closed cell foams in an occlusive hydrophilic polyacrylate matrix. The delivery of oxygen from the closed cells should largely occur through directional diffusion of dissolved oxygen in the fluid gradient derived from the exudating wound bed. Since oxygen delivery to hypoxic tissues is dependent upon diffusion through extravascular fluids, such a device may provide an economical and effective material for management of oxygen tension of the wound environment to support metabolic processes necessary to effect wound closure. The successful development of such an oxygen delivery device should provide for a cost effective solution for providing the benefits of supplemental oxygen therapy to a wider range of patients. PROPOSED COMMERCIAL APPLICATION: This study will evaluate the feasibility of the formation of an oxygen containing closed cell foam for use as a primary wound contact matrix intended for the delivery of oxygen to hypoxic tissues. The near term practical application of this technology is in wound management devices for increasing local tissue oxygen tension. It is envisioned that the formation of a material that captures and stores significant amounds of oxygen for delivery by diffusion would have uses that extend beyond wound care where there is a temporary or prolonged need to deliver biologically significant amounds of oxygen for medical and non-medical applications.

描述（逐字研究申请人摘要）：超过1500万 仅美国的患者就会患有顽固的非治疗伤口 估计支出超过100亿美元的治疗费用。这 人口寿命的变化将意味着人口基础的增加 这是遭受慢性非治疗伤口的风险。有一个很棒的 需要改进治疗慢性伤口的方法以促进更好的伤口 康复。尽管导致顽固伤口的关系是 复杂，人们众所周知，低氧之间有很强的相关性 张力和慢性非治疗状态存在。临床干预措施 致力于增加组织再灌注和组织氧合已 得到了慢性伤口愈合的重大改善。 但是，实现组织氧合的改善涉及昂贵的手术或 用于输送高压氧的特殊复杂设备。具体 这项研究的目的是评估开发一种材料的可行性 将以持续释放方式将O2传递到伤口环境中。这 研究旨在评估产生化学的利用 在闭塞亲水性中形成含氧的闭孔泡沫 聚丙烯酸酯基质。从封闭细胞中递送氧气应 在很大程度上通过溶解氧在流体中的方向扩散发生 梯度来自渗出的伤口床。因为氧递送到低氧 组织取决于通过血管外流体的扩散，这种装置 可以为氧气管理提供经济有效的材料 伤口环境的张力支持需要的代谢过程 效应伤口闭合。这种氧气递送的成功发展 设备应提供具有成本效益的解决方案，以提供收益 对更广泛的患者的补充氧疗法。 拟议的商业应用： 这项研究将评估含有闭合细胞的氧气形成的可行性 泡沫用作主要伤口接触矩阵，用于将氧气输送到 低氧组织。 该技术的短期实际应用是在伤口中 用于增加局部组织氧张力的管理设备。 可以预见的是 捕获和存储大量氧气的材料的形成以递送 通过扩散，将有超出伤口护理的使用 或长时间需要提供具有生物学意义的氧气和医学和 非医学应用。