RAMAN DETECTION OF HUMAN MACULAR CAROTENOID PIGMENTS

人黄斑类胡萝卜素色素的拉曼检测

• 批准号: 6293224
• 负责人: WERNER GELLERMANN
• 金额: $ 24.57万
• 依托单位: SPECTROTEK CORPORATION, LC
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6293224
• 关键词: Primates; Raman spectrometry; biomedical equipment development; carotenoids; charge coupled device camera; diagnosis design /evaluation; eye disorder diagnosis; fiber optics; holography; human subject; lasers; macular degeneration; macular drusen; retina

DESCRIPTION: The goal of this project is to develop a novel, non-invasive laser-optical technology for early diagnosis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly in the United States. The proposed development of a compact, low-cost diagnostic apparatus could ultimately provide the ophthalmologic and optometric communities with a powerful new screening test for AMD risk. The new technology uses Raman spectroscopy to detect the macular carotenoids lutein and zeaxanthin in the human retina. Recent basic and clinical science studies have indicated that these carotenoid compounds play a pivotal role in protecting the human macular from light-induced oxidative damage. Based on Phase I results, the Raman technology has the potential to provide a sensitive, fast, quantitative and objective optical detection of macular carotenoids. We propose to develop the Raman instrumentation, in the second phase, from an existing apparatus into a robust device useful for routine use in a clinical setting. Furthermore, we propose a series of clinical studies in humans to validate its function and to begin to establish its role as a possible screening test for AMD. PROPOSED COMMERCIAL APPLICATION: Screening of macular pigment levels.

描述：该项目的目标是开发一种新颖的、非侵入性的 激光光学技术用于年龄相关性黄斑的早期诊断 变性（AMD）是美国老年人失明的主要原因 国家。提议开发紧凑、低成本的诊断设备 最终可以为眼科和验光界提供 针对 AMD 风险的强大新筛查测试。新技术利用拉曼 光谱法检测黄斑中的类胡萝卜素、叶黄素和玉米黄质 人类视网膜。最近的基础和临床科学研究表明， 这些类胡萝卜素化合物在保护人类黄斑方面发挥着关键作用 免受光诱导的氧化损伤。根据第一阶段的结果，拉曼 技术有潜力提供灵敏、快速、定量和 黄斑类胡萝卜素的客观光学检测。我们建议开发 拉曼仪器，在第二阶段，从现有设备转变为 坚固的设备可用于临床环境中的常规使用。此外，我们 提出了一系列人体临床研究来验证其功能并 开始确立其作为 AMD 可能筛查测试的作用。 拟议的商业应用： 筛查黄斑色素水平。