GLYCOXIDATION AND DIABETIC RETINOPATHY

糖氧化和糖尿病视网膜病变

• 批准号: 6308158
• 负责人: TIMOTHY J LYONS
• 金额: $ 1.74万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308158
• 关键词: cardiovascular disorder; clinical research; collagen; diabetic retinopathy; human subject; hyperglycemia; medical complication; oxidation reduction reaction; oxidative stress; skin

The aim of the proposed study is to test the "glycoxidation hypothesis", which states that variations in oxidative stress among diabetic patients modulate the consequences of long-term hypoglycemia, specifically in determining the development of microvascular complications. The specific Aims are: To determine levels of glycoxidation products in skin collagen from complication-prone and complication-resistant diabetic patients (defined by retinopathy), and from non-diabetic control Using the data from control subjects to predict levels and rates of accumulation of glycoxidation products in skin collagen from individual diabetic patients, considering their long-term glycemic control, age and duration of diabetes. To compare predicted and actual levels and rates of accumulation of glycoxidation products in the two groups of diabetic patients, thereby deriving indices of relative long-term oxidative stress. According to the glycoxidation hypothesis, patients in the complication-prone group will have higher long-term oxidative stress than those in the complication-resistant group.

这项拟议研究的目的是测试“糖氧化假说”，该假说指出糖尿病患者氧化应激的变化会调节长期低血糖的后果，特别是在确定微血管并发症的发展方面。 具体目标是：确定易并发症和难并发症糖尿病患者（定义为视网膜病变）和非糖尿病对照的皮肤胶原蛋白中的糖基氧化产物水平。使用对照受试者的数据预测个体糖尿病患者皮肤胶原蛋白中糖基氧化产物的积累水平和速率，考虑其长期血糖控制、年龄和糖尿病持续时间。比较两组糖尿病患者中预测和实际的糖基氧化产物积累水平和速率，从而得出相对长期氧化应激指数。 根据糖氧化假说，并发症易感组的患者将比并发症抵抗组的患者具有更高的长期氧化应激。