GLYCOXIDATION AND DIABETIC RETINOPATHY

该研究的目的是验证“糖氧化假说”，即糖尿病患者氧化应激的变化调节长期低血糖的后果，特别是决定微血管并发症的发展。具体目的是：测定易发生并发症和不易发生并发症的糖尿病患者（由视网膜病变定义）和非糖尿病对照组皮肤胶原蛋白中糖氧化产物的水平。利用对照组的数据，考虑到糖尿病患者的长期血糖控制、年龄和糖尿病病程，预测个体糖尿病患者皮肤胶原蛋白中糖氧化产物的水平和积累速率。比较两组糖尿病患者预测和实际的糖氧化产物积累水平和速率，从而得出相对长期氧化应激的指标。根据糖氧化假说，并发症易发组患者的长期氧化应激高于抗并发症组。

The aim of the proposed study is to test the "glycoxidation hypothesis", which states that variations in oxidative stress among diabetic patients modulate the consequences of long-term hypoglycemia, specifically in determining the development of microvascular complications. The specific Aims are: To determine levels of glycoxidation products in skin collagen from complication-prone and complication-resistant diabetic patients (defined by retinopathy), and from non-diabetic control Using the data from control subjects to predict levels and rates of accumulation of glycoxidation products in skin collagen from individual diabetic patients, considering their long-term glycemic control, age and duration of diabetes. To compare predicted and actual levels and rates of accumulation of glycoxidation products in the two groups of diabetic patients, thereby deriving indices of relative long-term oxidative stress. According to the glycoxidation hypothesis, patients in the complication-prone group will have higher long-term oxidative stress than those in the complication-resistant group.