GLYCOXIDATION AND DIABETIC RETINOPATHY

这项研究的目的是验证“糖氧化假说”，该假说认为糖尿病患者的氧化应激变化会调节长期低血糖的后果，特别是在确定微血管并发症的发展方面。具体目标是：根据糖尿病患者的长期血糖控制、年龄和病程，使用来自对照受试者的数据来预测个体糖尿病患者皮肤胶原中糖氧化产物的水平和累积速率，以确定易并发症和难治性糖尿病患者(由视网膜病变定义)和非糖尿病对照组皮肤胶原中糖氧化产物的水平。比较两组糖尿病患者体内糖氧化产物的预测水平和积累率，从而得出相对长期氧化应激指数。根据糖氧化假说，并发症易发组患者的长期氧化应激水平高于并发症耐受组。

The aim of the proposed study is to test the "glycoxidation hypothesis", which states that variations in oxidative stress among diabetic patients modulate the consequences of long-term hypoglycemia, specifically in determining the development of microvascular complications. The specific Aims are: To determine levels of glycoxidation products in skin collagen from complication-prone and complication-resistant diabetic patients (defined by retinopathy), and from non-diabetic control Using the data from control subjects to predict levels and rates of accumulation of glycoxidation products in skin collagen from individual diabetic patients, considering their long-term glycemic control, age and duration of diabetes. To compare predicted and actual levels and rates of accumulation of glycoxidation products in the two groups of diabetic patients, thereby deriving indices of relative long-term oxidative stress. According to the glycoxidation hypothesis, patients in the complication-prone group will have higher long-term oxidative stress than those in the complication-resistant group.