NATURAL HISTORY, PREVENTION AND TREATMENT OF RECURRENT VIRAL HEPATITIS B & C

肝移植后免疫抑制、排斥反应和去神经支配对利多卡因和吲哚菁绿代谢影响的研究。肝移植已成为终末期肝病患者广泛应用的治疗手段。在改进手术技术、改善供体器官保存、加强术后即时护理、早期识别和治疗移植组织排斥反应等方面取得了重大进展。这种手术和术后护理的改善导致肝移植受者存活率的显著提高。许多中心报告说，一年存活率超过80%，而十年前只有50%。随着生存率的提高和大量患者随访时间的延长，很明显，对于移植肝和肝移植患者的长期情况，有很多需要了解的地方。调查人员的一些担忧是：移植物功能的一般情况、急性排斥反应的发生率、诊断和原因、慢性排斥反应的发生率、诊断和自然史、长期免疫抑制的适当水平和免疫抑制相关并发症的发生率、原发性肝脏疾病的复发率、非直接归因于免疫抑制的移植物功能障碍的发展。移植对移植患者营养状况的影响，以及移植对移植患者生活质量的影响。接受肝移植的患者是本研究的潜在候选者。

A study to determine the effect of immunosupression, rejection, and denervation on lidocaine and indocyanine green metabolism after liver transplant. Liver transplant has become a widely applied therapeutic measure for patients with end-stage liver disease. Significant progress has been made in refining the surgical technique, improving donor organ preservation, enhancing the immediate post-operative care, and in the early recognition and treatment of grafted tissue rejection. Such improvements in operative and post-operative care have resulted in a dramatic increase in survival of liver transplant recipients. Many centers are reporting one-year survival rates of over 80%, compared to 50%, ten years ago. As survival improved and larger numbers of patients were followed for longer periods of time, it became clear that much needed to be learned about both the transplanted liver and the liver transplant patient in the long-term setting. Some of the concerns of the investigators are: graft function in general, incidence, diagnosis, and cause of acute rejection outside the immediate post operative period, incidence, diagnosis, and natural history of chronic rejection, the appropriate level of immunosupression in the long-term setting and the incidence of immunosupression associated complications, the incidence of recurrence of the primary liver disease, the development of graft dysfunction not directly attributed to immunosupression, the effect of transplantation on the nutritional status of the transplant patient, and the effect of transplantation on the quality of life of the transplant patient. Patients undergoing liver transplantation are potential candidates for this study.