NATURAL HISTORY, PREVENTION AND TREATMENT OF RECURRENT VIRAL HEPATITIS B & C

复发性乙型病毒性肝炎的自然史、预防和治疗

• 批准号: 6304981
• 负责人: Mitchell L Shiffman
• 金额: $ 0.06万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304981
• 关键词: clinical research; clinical trials; combination therapy; drug screening /evaluation; hepatitis B; hepatitis C; hepatitis C virus; human subject; human therapy evaluation; immunoglobulins; immunotherapy; interferon alpha; lamivudine; liver disorder chemotherapy; liver transplantation; longitudinal human study; nucleoside analog; outcomes research; pathologic process; postoperative complications; relapse /recurrence

A study to determine the effect of immunosupression, rejection, and denervation on lidocaine and indocyanine green metabolism after liver transplant. Liver transplant has become a widely applied therapeutic measure for patients with end-stage liver disease. Significant progress has been made in refining the surgical technique, improving donor organ preservation, enhancing the immediate post-operative care, and in the early recognition and treatment of grafted tissue rejection. Such improvements in operative and post-operative care have resulted in a dramatic increase in survival of liver transplant recipients. Many centers are reporting one-year survival rates of over 80%, compared to 50%, ten years ago. As survival improved and larger numbers of patients were followed for longer periods of time, it became clear that much needed to be learned about both the transplanted liver and the liver transplant patient in the long-term setting. Some of the concerns of the investigators are: graft function in general, incidence, diagnosis, and cause of acute rejection outside the immediate post operative period, incidence, diagnosis, and natural history of chronic rejection, the appropriate level of immunosupression in the long-term setting and the incidence of immunosupression associated complications, the incidence of recurrence of the primary liver disease, the development of graft dysfunction not directly attributed to immunosupression, the effect of transplantation on the nutritional status of the transplant patient, and the effect of transplantation on the quality of life of the transplant patient. Patients undergoing liver transplantation are potential candidates for this study.

免疫抑制、排斥反应和去神经支配对肝移植术后利多卡因和吲哚菁绿色代谢影响的研究。肝移植已成为终末期肝病患者广泛采用的治疗措施。在改进手术技术、改善供体器官保存、加强术后即时护理以及移植组织排斥反应的早期识别和治疗方面取得了重大进展。手术和术后护理的这种改善导致肝移植受者的存活率显著增加。许多中心报告的一年生存率超过80%，而十年前为50%。随着生存率的提高和更长时间的随访患者数量的增加，很明显，在长期环境中，需要对移植肝脏和肝移植患者进行更多的了解。调查人员的一些关切是：一般移植物功能，术后即刻期外急性排斥反应的发生率、诊断和原因，慢性排斥反应的发生率、诊断和自然史，长期环境中适当的免疫抑制水平和免疫抑制相关并发症的发生率，原发性肝病复发的发生率，不直接归因于免疫抑制的移植物功能障碍的发展、移植对移植患者营养状况的影响以及移植对移植患者生活质量的影响。接受肝移植的患者是本研究的潜在候选人。