IDIOTYPE VACCINATION AFTER BMT FOR B CELL MALIGNANCIES
IDIOTYPE VACCINATION AFTER BMT FOR B CELL MALIGNANCIES
批准号:
6305160
负责人:
RONALD LEVY
金额:
$0.06万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-12-01 至 2000-11-30
关键词:
B lymphocyte active immunization autologous transplantation bone marrow transplantation clinical research dendritic cells human subject human therapy evaluation immunotherapy leukocyte activation /transformation multiple myeloma neoplasm /cancer therapy neoplasm /cancer vaccine nonHodgkin's lymphoma
中文摘要
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英文摘要
This trial is designed to test the safety, immunogenicity, and clinical activity of autologous peripheral blood dendritic cells (DCs) pulsed with tumor-derived idiotype protein in patients who have undergone high dose therapy and stem cell rescue for B cell lymphomas and multiple myeloma. The long-term goal of this study is to develop a vaccine therapy which will induce a clinically effective immune responses. The vaccine is produced on a custom basis from each patient's tumor cells and peripheral blood dendritic cells. In pilot studies in lymphoma, cellular immune responses and tumor regressions have been observed.
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