GENERAL CLINICAL RESEARCH CENTER

这是对纽约医院-康奈尔医学中心儿童临床研究中心(CCRC)的多部门和多类别拨款申请的重新提交，该中心是康奈尔大学医学院(CUMC)临床研究和临床研究培训计划的关键焦点之一。这项提议要求为儿童临床研究中心提供五年的持续支持，临床研究人员可以在该中心进行研究，以在最佳研究环境下增加他们对人类正常功能和疾病机制的了解。该中心提供一个独立的住院病房，有8张研究床位和一个门诊设施，用于儿童非卧床研究对象。目前的CCRC激素分析实验室为不同数量的研究人员和项目提供具有成本效益的、非常规的、有质量控制的激素分析。我们希望增加许多新议定书的科学需求。除了为CUMC的研究设施提供服务外，该中心还向附属医院的临床研究人员提供服务，如高科技三级保健综合医院的住院和门诊研究资源。目前和计划的项目包括内分泌学和新陈代谢、高血压、血液学、传染病、风湿学、免疫学、遗传学、神经学、药理学、精神病学以及胶原合成和结缔组织与疾病的关系等领域的研究。利用CCRC资源研究的疾病是复杂的，往往是多学科的，具有相当大的生物、医学和/或公共卫生意义。根据对上一次提交的批评，本申请已进行了重大修改，所有批评都已得到解决。

This is a resubmission of a multi-departmental and multi-categorical grant application for the Children's Clinical Research Center (CCRC) at The New York Hospital-Cornell Medical Center, which serves as one of the key focal points for Cornell University Medical College's (CUMC) programs in clinical investigation and in clinical research training. This proposal requests five years of continued support for the Children's Clinical Research Center, where clinical investigators can pursue studies to increase their understanding of normal function and disease mechanisms in humans in an optimal research setting. The Center provides a discrete inpatient unit with 8 research beds and an outpatient facility for child ambulatory research subjects. The current CCRC Hormone Assay Laboratory provides cost effective, non-routine, quality-controlled hormone assays for a diverse number of investigators and projects. We wish to add scientific needs of many new protocols. In addition to serving the research facility of CUMC, the center is also available to clinical investigators at affiliated hospitals, as in inpatient and ambulatory research resource within a high technology, tertiary-care general hospital. Current and projected projects include studies in the areas of endocrinology and metabolism hypertension, hematology, infectious disease, rheumatology, immunology, genetics, neurology, pharmacology, psychiatry, and the relationship of collagen synthesis and connective tissue to disease. Diseases under study utilizing the CCRC resource are complex and often multi-disciplinary in scope, and of considerable biological, medical, and/or public health significance. Based on the critique of the last submission, this application has undergone substantial revisions and all the criticisms have been addressed.