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Mechanisms of post-transcriptional regulation of MeCP2

Mechanisms of post-transcriptional regulation of MeCP2
MeCP2转录后调控机制
批准号:
6506556
负责人:
CAROL S LUTZ
金额:
$7.78万
依托单位国家:
美国
项目类别:
财政年份:
2002
资助国家:
美国
项目状态:
已结题
起止时间:
2002-07-01 至 2004-06-30

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): The goal of this application is to uncover the sequences and factors involved in the regulation of the formation and function of the unusually large 3' untranslated region of the MeCP2 gene. This approximately 8.5 kb 3' UTR likely contains elements that regulate gene expression at the post-transcriptional level. First, the investigators will identify auxiliary regulatory elements and factors that play a role in alternative polyadenylation of the MeCP2 gene, the process that determines the size of the 3' UTR in a tissue- and developmental-specific fashion. Second, they will test the hypothesis that the long 3' UTR plays a role in determining differential stability or translation of the MeCP2 mRNA. These studies represent under-explored areas of MeCP2 expression that may have a critical influence in the tissue-specific effects observed in Rett syndrome.
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Computational and Experimental Analysis of RNA structures in mRNA polyadenylation
Computational and Experimental Analysis of RNA structures in mRNA polyadenylation
Mechanisms of MeCP2 gene expression regulation
3' end formation of human type I and II collagen mRNAs
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