NEW CONCEPTS AND TREATMENT FOR SPATIAL NEGLECT

描述(申请人提供)：空间忽视(忽略)，一种常见的， 中风后的致残状态预示着较差的康复结果。 基于空间表征的当代忽视理论 通过其引导注意力和运动，不能解释许多 最近的经验发现。治疗的好处可能是有限的，因为 理论是不完整的。这项提案的研究将调查一种新的 忽视的概念，并将这一概念应用于治疗。调查人员想要 拓宽忽视理论的框架。他们提出，在某些方面 忽视行为反映了对空间的改变，而其他人 反映出刺激强度的变化。这是一个假设 建议是，刺激强度的表示法在 符合心理物理学中的幂定律。幂定律描述了一个 刺激的物理强度与其强度之间的定量关系 感知强度，它适用于各种感觉模式。它是 基于比率标度的概念--刺激的相等比率 强度产生与感知强度相同的比率。比例缩放是 通过使用权力职能，在本提案中得以运作。这个 研究人员的初步工作表明，对忽视的经验约束 理论可以用一个结合了空间概念的理论来解释 表示刺激强度的表示法。目标1是扩展 调查人员对8个知觉的比例尺的初步研究 康涅瓦。目标2是比较有和没有的患者的比率比例。 左侧和右侧缺血性卒中后的忽视 大脑半球和非患者对照。目标3是比较患者和 接受过忽视训练的人与未接受过训练的人，在与以下方面相关的结果方面进行比率衡量 忽视和日常生活活动。维持治疗福利超过 时间将被评估。结果将支持或修改 研究人员的核心假设。调查人员预料到了这一点 Proposal的研究将导致一个全面的忽视理论和一个 对权力法则的全面解读。他们将促进理解 心理表征和大脑皮层的多面性 对比率调整的贡献。调查人员预计，目标3将会产生 一种可广泛应用于康复的治疗方法 在真实环境中提高真实任务的性能。

DESCRIPTION (provided by applicant): Spatial neglect (neglect), a common, disabling condition following stroke, predicts poor rehabilitation outcome. Contemporary theories of neglect, predicated on spatial representations through which attention and movement are directed, cannot explain a number of recent empirical findings.Treatment may be of limited benefit because the theories are incomplete. Research in this proposal will investigate a new concept in neglect and apply this concept in treatment. The investigators want to broaden the framework of neglect theory. They propose that some aspects of neglect behavior reflect altered representations of space, whereas others reflect altered representations of stimulus intensity. The hypothesis of this proposal is that representations of stimulus intensity are derived in accordance with the Power-Law in psychophysics. The Power-Law describes a quantitative relationship between the physical intensity of a stimulus and its perceived intensity, and it applies across sensory modalities. It is predicated on the concept of ratio scaling -- equal ratios of stimulus intensity produce equal ratios of perceived intensity. Ratio scaling is operationalized in this proposal through use of power functions. The investigators' preliminary work shows that empirical constraints on neglect theory can be explained by a theory that combines the concepts of spatial representations with representation of stimulus intensity. Aim 1 is to extend the investigators preliminary work by examining ratio scaling in 8 perceptual continua. Aim 2 is to compare ratio scaling among patients with and without neglect following unilateral ischemic strokes of the left and right hemispheres and non-patient controls. Aim 3 is to compare patients with neglect trained vs. those untrained in ratio scaling on outcomes related to neglect and activities of daily living. Maintenance of treatment benefits over time will be assessed. Results will either support or modify the investigators' central hypothesis. The investigators anticipate this proposal's studies will lead to a comprehensive theory of neglect and a comprehensive interpretation of the Power-Law. They will advance understanding of the multi-faceted nature of mental representation and the cortical contributions to ratio scaling. The investigators anticipate Aim 3 will yield a treatment approach that can be widely applied in rehabilitation and can improve performance on real-life tasks in real-life settings.