NEW CONCEPTS AND TREATMENT FOR SPATIAL NEGLECT

空间忽视的新概念和治疗方法

• 批准号: 6536367
• 负责人: MARK S MENNEMEIER
• 金额: $ 6.27万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6536367
• 关键词: behavior disorders; behavioral /social science research tag; bias; functional ability; human middle age (35-64); human old age (65+); human subject; medical rehabilitation related tag; patient oriented research; perception; perception disorder; psychological tests; psychomotor function; psychophysics; rehabilitation; sensory discrimination; sensory thresholds; space perception; statistics /biometry; stimulus /response; stroke therapy; technology /technique development; training

DESCRIPTION (provided by applicant): Spatial neglect (neglect), a common, disabling condition following stroke, predicts poor rehabilitation outcome. Contemporary theories of neglect, predicated on spatial representations through which attention and movement are directed, cannot explain a number of recent empirical findings.Treatment may be of limited benefit because the theories are incomplete. Research in this proposal will investigate a new concept in neglect and apply this concept in treatment. The investigators want to broaden the framework of neglect theory. They propose that some aspects of neglect behavior reflect altered representations of space, whereas others reflect altered representations of stimulus intensity. The hypothesis of this proposal is that representations of stimulus intensity are derived in accordance with the Power-Law in psychophysics. The Power-Law describes a quantitative relationship between the physical intensity of a stimulus and its perceived intensity, and it applies across sensory modalities. It is predicated on the concept of ratio scaling -- equal ratios of stimulus intensity produce equal ratios of perceived intensity. Ratio scaling is operationalized in this proposal through use of power functions. The investigators' preliminary work shows that empirical constraints on neglect theory can be explained by a theory that combines the concepts of spatial representations with representation of stimulus intensity. Aim 1 is to extend the investigators preliminary work by examining ratio scaling in 8 perceptual continua. Aim 2 is to compare ratio scaling among patients with and without neglect following unilateral ischemic strokes of the left and right hemispheres and non-patient controls. Aim 3 is to compare patients with neglect trained vs. those untrained in ratio scaling on outcomes related to neglect and activities of daily living. Maintenance of treatment benefits over time will be assessed. Results will either support or modify the investigators' central hypothesis. The investigators anticipate this proposal's studies will lead to a comprehensive theory of neglect and a comprehensive interpretation of the Power-Law. They will advance understanding of the multi-faceted nature of mental representation and the cortical contributions to ratio scaling. The investigators anticipate Aim 3 will yield a treatment approach that can be widely applied in rehabilitation and can improve performance on real-life tasks in real-life settings.

描述（由申请人提供）：空间忽视（忽视），一种常见的，

项目成果

Are psychophysical functions derived from line bisection reliable?

由线平分得出的心理物理函数可靠吗？

• DOI: 10.1017/s1355617703910083
• 发表时间: 2003
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Pierce,ChristopherA;Jewell,George;Mennemeier,Mark
• 通讯作者: Mennemeier,Mark

Biases in attentional orientation and magnitude estimation explain crossover: neglect is a disorder of both.

注意方向和强度估计的偏差解释了交叉：忽视是两者的障碍。

• DOI: 10.1162/0898929055002454
• 发表时间: 2005
• 期刊: Journal of cognitive neuroscience.
• 作者: Mennemeier,Mark;Pierce,ChristopherA;Chatterjee,Anjan;Anderson,Britt;Jewell,George;Dowler,Rachael;Woods,AdamJ;Glenn,Tannahill;Mark,VictorW
• 通讯作者: Mark,VictorW

Just thinking about targets can aggravate neglect on cancellation tests.

仅仅考虑目标可能会加剧对取消测试的忽视。

• DOI: 10.1080/13554790490960468
• 发表时间: 2004
• 期刊: Neurocase
• 影响因子: 0.8
• 作者: Mennemeier,MS;Morris,M;Heilman,KM
• 通讯作者: Heilman,KM

Maintenance repetitive transcranial magnetic stimulation can inhibit the return of tinnitus.

维持重复经颅磁刺激可以抑制耳鸣的复发。

• DOI: 10.1097/mlg.0b013e318170f8ac
• 发表时间: 2008
• 期刊: The Laryngoscope
• 作者: Mennemeier,Mark;Chelette,KennethC;Myhill,Jeffery;Taylor-Cooke,Patricia;Bartel,Twyla;Triggs,William;Kimbrell,Timothy;Dornhoffer,John
• 通讯作者: Dornhoffer,John

Using repetitive transcranial magnetic stimulation for the treatment of tinnitus.

使用重复经颅磁刺激治疗耳鸣。

• DOI: 10.1097/01.hj.0000390816.71876.aa
• 发表时间: 2010
• 期刊: The Hearing journal
• 作者: Dornhoffer,JohnL;Mennemeier,Mark
• 通讯作者: Mennemeier,Mark