NEW CONCEPTS AND TREATMENT FOR SPATIAL NEGLECT

空间忽视的新概念和治疗方法

• 批准号: 6322216
• 负责人: MARK S MENNEMEIER
• 金额: $ 6.2万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2003-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6322216
• 关键词: behavior disorders; behavioral /social science research tag; bias; functional ability; human middle age (35-64); human old age (65+); human subject; medical rehabilitation related tag; patient oriented research; perception; perception disorder; psychological tests; psychomotor function; psychophysics; rehabilitation; sensory discrimination; sensory thresholds; space perception; statistics /biometry; stimulus /response; stroke therapy; technology /technique development; training

DESCRIPTION (provided by applicant): Spatial neglect (neglect), a common, disabling condition following stroke, predicts poor rehabilitation outcome. Contemporary theories of neglect, predicated on spatial representations through which attention and movement are directed, cannot explain a number of recent empirical findings.Treatment may be of limited benefit because the theories are incomplete. Research in this proposal will investigate a new concept in neglect and apply this concept in treatment. The investigators want to broaden the framework of neglect theory. They propose that some aspects of neglect behavior reflect altered representations of space, whereas others reflect altered representations of stimulus intensity. The hypothesis of this proposal is that representations of stimulus intensity are derived in accordance with the Power-Law in psychophysics. The Power-Law describes a quantitative relationship between the physical intensity of a stimulus and its perceived intensity, and it applies across sensory modalities. It is predicated on the concept of ratio scaling -- equal ratios of stimulus intensity produce equal ratios of perceived intensity. Ratio scaling is operationalized in this proposal through use of power functions. The investigators' preliminary work shows that empirical constraints on neglect theory can be explained by a theory that combines the concepts of spatial representations with representation of stimulus intensity. Aim 1 is to extend the investigators preliminary work by examining ratio scaling in 8 perceptual continua. Aim 2 is to compare ratio scaling among patients with and without neglect following unilateral ischemic strokes of the left and right hemispheres and non-patient controls. Aim 3 is to compare patients with neglect trained vs. those untrained in ratio scaling on outcomes related to neglect and activities of daily living. Maintenance of treatment benefits over time will be assessed. Results will either support or modify the investigators' central hypothesis. The investigators anticipate this proposal's studies will lead to a comprehensive theory of neglect and a comprehensive interpretation of the Power-Law. They will advance understanding of the multi-faceted nature of mental representation and the cortical contributions to ratio scaling. The investigators anticipate Aim 3 will yield a treatment approach that can be widely applied in rehabilitation and can improve performance on real-life tasks in real-life settings.

描述（由申请人提供）：空间忽视（忽视），一种常见的， 中风后的残疾状况，预示着不良的康复结果。 基于空间表征的当代忽视理论 注意力和运动的方向，不能解释一些 最近的实证研究结果。治疗可能是有限的好处，因为 理论不完整。本提案中的研究将调查一种新的 并将这一概念应用于治疗。调查人员希望 拓宽了忽视理论的框架他们提出， 忽视行为反映了空间表征的改变，而其他行为则反映了空间表征的改变。 反映了刺激强度的改变。这个假设 建议是刺激强度的表示来自于 符合心理物理学中的幂律幂律描述了一个 刺激的物理强度与其 感知强度，它适用于各种感官形式。是 基于比例缩放的概念--刺激的比例相等 强度产生相等感知强度比率。比例缩放是 通过使用幂函数在该提议中可操作化。的 调查人员的初步工作表明，忽视的经验限制， 理论可以解释的理论，结合了空间的概念， 表示刺激强度的表示。目标1：扩展 研究人员通过检查8个知觉的比例缩放进行了初步工作， continua。目的2是比较有和没有的患者之间的比例缩放 左侧和右侧单侧缺血性卒中后的忽视 半球和非患者对照。目的3是比较患者与 在与下列方面有关的结果的比例缩放方面，接受过培训的人与未接受过培训的人相比， 忽视和日常生活活动。维持治疗获益超过 时间将被评估。结果将支持或修改 研究者的中心假设调查人员预计， 提案的研究将导致一个全面的忽视理论和一个 全面解读幂律。他们将促进理解 心理表征的多面性和大脑皮层 对比例缩放的贡献调查人员预计，Aim 3将产生 一种可以广泛应用于康复的治疗方法， 提高在现实生活中的现实生活中的任务的性能。