Core--Biostatistics

核心--生物统计学

• 批准号: 6500491
• 负责人: VARGHESE GEORGE
• 金额: $ 32.87万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6500491
• 关键词: biomedical facility; computer data analysis; data management; experimental designs; genetic mapping; mathematical model; myocardial ischemia /hypoxia; statistics /biometry

A. INTRODUCTION An experienced interdisciplinary research team is formed to solve important basic science and clinical questions related to the goals of this SCOR project. The main purpose of the Biostatistics Core is to bring together the information from different sources into an integrated database, and coordinate the genetic and statistical analyses with the focused being on the main goals of the SCOR. Since ischemia is a complex, multi-factorial and genetically heterogeneous disorder, different types of investigations are now being proposed in this core, which will require distinctly different analytical methods. One of the major goals of this core is to choose appropriate analytical and statistical techniques for the analysis of data collected from different analytical methods. One of the major goals of this core is to choose appropriate analytical and statistical techniques for the analysis of data collected from different projects in this SCOR proposal, especially, focusing on the justification of the data analysis method to be used for each type of data generated. B. Specific Aims: 1. Design and apply analytical methods to be used in the gene mapping and other quantitative studies associated with various projects in the SCOR. 2. Provide ongoing statistical consultation to research projects, focusing on issues such as experimental design, sample size, aptness and validity of models to be used, power consideration and interpretation of the results. 3. Maintain a dataflow system that insures accuracy, security, validation and archiving of all data collected for different projects of the SCOR.

为解决与本SCOR项目目标相关的重要基础科学和临床问题，组建了一支经验丰富的跨学科研究团队。生物统计核心的主要目的是将来自不同来源的信息汇集到一个综合数据库中，并协调遗传和统计分析，重点放在SCOR的主要目标上。由于缺血是一种复杂的、多因素的、遗传异质性的疾病，目前在这一核心领域提出了不同类型的研究，这将需要明显不同的分析方法。该核心的主要目标之一是选择适当的分析和统计技术来分析从不同的分析方法收集的数据。该核心的主要目标之一是选择适当的分析和统计技术来分析本SCOR提案中从不同项目收集的数据，特别是侧重于对所生成的每种数据类型使用的数据分析方法的合理性。B.具体目标：设计和应用分析方法，用于基因定位和其他定量研究相关的各种项目在SCOR。2. 为研究项目提供持续的统计咨询，重点关注实验设计，样本量，所使用模型的适用性和有效性，功率考虑和结果解释等问题。3. 维护数据流系统，确保SCOR不同项目收集的所有数据的准确性，安全性，有效性和存档。