Biostatistics & Data Management Core

生物统计学

• 批准号: 8701552
• 负责人: VARGHESE GEORGE
• 金额: $ 24.7万
• 依托单位: AUGUSTA UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8701552
• 关键词: Accounting; Address; Archives; Biometry; Clinical; Consultations; Correlation Studies; Data; Data Analyses; Databases; Development; Diet; Experimental Designs; Goals; Hypertension; Investigation; Manuscripts; Methods; Modeling; Obesity; Pathway interactions; Preparation; Public Health; Publications; Quality Control; Research Design; Research Personnel; Research Project Grants; Risk; Risk Factors; Role; Sample Size; Security; Source; Stress; System; Techniques; Therapeutic Intervention; Validation; analytical method; data management; design; programs

The main purpose of the Biostatistics and Data Management Core (Core C) is to bring together the information from different sources into an integrated database, and to coordinate the statistical analyses with the focus being on the main goals of the PPG. A secondary role will be to resolve any methodological issues resulting from the analyses of the Program Project data. The overarching goal of our PPG is to identify pathways that account for the synergistic effects of stress, obesity and diet in the development of hypertension that are open to therapeutic intervention. Different types of investigations are being proposed in this project to accomplish this goal. This will require distinctly different design and analytical methods. The Biostatistics and Data Management Core will help the investigators of the projects to choose appropriate experimental designs and analytical techniques tailored to address specific hypotheses, especially, focusing on justification of the data analysis method to be used for each type of data generated. The Core will also serve as the focus for data compilation, quality control, data management, data analysis and interpretation support for the PPG. To that extent, we propose the following three Specific Aims: (1) Design and apply analytical methods to be used in the quantitative studies associated with each of the projects in the PPG; (2) Provide ongoing statistical consultation to research projects, focusing on issues such as experimental design, sample size, aptness and validity of models to be used, power considerations, interpretation of results, and preparation of manuscripts for presentations and publications; and, (3) Maintain a dataflow system that insures accuracy, security, validation and archiving of all data collected for the projects of the PPG.

生物统计和数据管理核心（核心C）的主要目的是将来自不同来源的信息汇集到一个综合数据库中，并协调统计分析，重点是PPG的主要目标。第二个作用是解决因分析计划项目数据而产生的任何方法问题。我们PPG的总体目标是确定在高血压发展过程中压力、肥胖和饮食的协同作用的途径，这些途径对治疗干预开放。为实现这一目标，本项目提出了不同类型的调查。这将需要明显不同的设计和分析方法。生物统计学和数据管理核心将帮助项目的研究人员选择适当的实验设计和分析技术，以解决特定的假设，特别是，侧重于数据分析方法的理由将用于生成的每种类型的数据。核心还将作为PPG的数据汇编、质量控制、数据管理、数据分析和解释支持的重点。为此，我们提出了以下三个具体目标：（1）设计和应用分析方法，用于与PPG中每个项目相关的定量研究;（2）为研究项目提供持续的统计咨询，重点是实验设计，样本大小，所用模型的适用性和有效性，功效考虑，结果解释，（3）维持一个可持续发展系统，确保为项目规划小组项目收集的所有数据的准确性、安全性、有效性和存档。