Core--Clinical evaluation

临床评估核心的目标是：(1)招募、表征和 跟踪参与CCNMD项目#2-7的所有人类受试者 (2)开发和维护最先进的临床方法 人体应激素质测试框架的表征 自杀行为的典范。CEC确定并招募了患有 生命周期(和尸检)中的MDE、BPD和精神分裂症。 招募正常的志愿者来提供规范的价值观 使用的临床和神经生物学措施以及建立心理测量学 非病态总体中度量的性质。CEC利用 涵盖重大风险的临床/神经心理学工具的核心 自杀行为的因子域，并确保 跨CCNMD项目的评估领域和措施。 这些评估包括Axis I和II诊断面谈、措施 与状态和特征相关的风险因素，神经心理评估， 自杀行为的测量，人口历史，生活事件，社会 功能正常，家族精神病史。评估在以下位置进行 生物程序时、出院时、3个月、1和2岁时的摄入量 一年的随访。CEC调查、开发和测试新的评估 应对自杀领域当前和未来需要的程序 研究，并定期审查工具的可靠性和有效性。 CEC通过评分者之间的交流确保临床评估的质量 可靠性调查使用现场采访或录音采访。在所有方面，我们的 学院为研究人员提供研究方法方面的咨询 和结果解释。CEC教职员工提供咨询以 研究方法和结果解释方面的研究人员。CEC 已经成功地招募并跟踪了适当的生活科目成员 在拟议的诊断和年龄类别中。培训和可靠性 在所有CCNMD评分员中，由CEC协调。CEC与 SCC员工在开发表单、数据管理程序和 CEC与BIC协调生成可靠性统计数据 关于招聘、面试、控制匹配和主题流程。 CEC从受试者身上获取血液和脑脊液 由《中图法》进行分析。CEC与管理核心接口 关于征聘新工作人员和维护中央数据库 在所有CEC手稿中。CEC协调所有诊断共识 会议。

The Clinical Evaluation Core's goals are to: (1) recruit, characterize, and follow all human subjects participating in projects #2-7 of the CCNMD (2) develop and maintain state-of-the-art methods for clinical characterization of human framework for testing the stress-diathesis model of suicidal behavior. The CEC identified and recruits patients with MDE, BPD, and Schizophrenia across the life cycle (and post-mortem). Normal volunteers are recruited to provide normative values on the clinical and neurobiological measures used and to establish psychometric properties of measures in a non-pathological population. The CEC utilizes a core of clinical/neuropsychological instruments covering major risk factor domains for suicidal behavior, and ensures uniformity of assessment domains and measures across the projects of the CCNMD. These assessments include Axis I and II diagnostic interviews, measures of state and trait-related risk factors, neuropsychological assessment, measures of suicidal behavior, demographic history, life events, social functioning, family psychiatric history. Assessments are performed at intake, at time of biological procedures, at discharge, at 3 month, 1 and 2 year follow-up. The CEC investigates, develops and tests new assessment procedures to address current and future needs in the field of suicide research, and regularly reviews the reliability and validity of instruments. The CEC ensures the quality of clinical assessments through inter-rater reliability rounds using live or taped interviews. On all measures, our faculty provides consultation to investigators in research methodology and result interpretation. The CEC faculty provides consultation to investigators in research methodology and result interpretation. The CEC has successfully recruited and followed adequate members of life subjects in the proposed diagnostic and age categories. The training and reliability of all CCNMD raters is coordinated by the CEC. The CEC works with SCC staff in developing forms, data management procedures and in generating reliability statistics The CEC coordinates with the BIC regarding recruitment, interviewing, control matching and subject flow. The CEC obtains the blood and cerebrospinal fluid from subjects to be analyzed by the CLC. The CEC interfaces with the Administrative Core regarding recruitment of new staff and maintenance of a central database of all CEC manuscripts. The CEC coordinates all diagnostic consensus conferences.