Core--Clinical evaluation

临床评价核心的目标是：（1）招募、表征和 跟踪参与CCNMD项目#2 - 7的所有人类受试者 (2)开发和维护最先进的临床方法， 人体应激素质测试框架的表征 自杀行为的模式。CEC确定并招募了以下患者： MDE，BPD和精神分裂症在整个生命周期（和死后）。 招募正常志愿者以提供关于 使用临床和神经生物学测量，并建立心理测量 在非病理人群中的测量的性质。CEC利用 涵盖主要风险的临床/神经心理学工具核心 自杀行为的因素域，并确保一致性， CCNMD项目的评估领域和措施。 这些评估包括轴I和轴II诊断性访谈、测量 状态和特质相关的风险因素，神经心理学评估， 自杀行为、人口统计学史、生活事件、社会 功能正常家族精神病史评估在 摄入、生物程序时、出院时、3个月、1个月和2个月 年的后续。CEC调查、开发和测试新的评估 解决自杀领域当前和未来需求的程序 研究，并定期审查工具的可靠性和有效性。 CEC通过评估者间评估确保临床评估的质量 可靠性轮使用现场或录音采访。从各个方面来看， 教师为研究人员提供研究方法方面的咨询 和结果解释。CEC教师提供咨询， 研究方法和结果解释。中央选举委员会 已经成功地招募并跟踪了足够的生命主体成员， 在诊断和年龄分类中。训练和可靠性 所有CCNMD评分员的评分由CEC协调。CEC与 SCC工作人员制定表格、数据管理程序， 生成可靠性统计信息CEC与BIC协调 关于招聘、面试、控制匹配和主题流程。 CEC从受试者获得血液和脑脊液， CLC分析。CEC与行政核心接口 关于征聘新工作人员和维持一个中央数据库 所有的CEC手稿。CEC协调所有诊断共识 两会

The Clinical Evaluation Core's goals are to: (1) recruit, characterize, and follow all human subjects participating in projects #2-7 of the CCNMD (2) develop and maintain state-of-the-art methods for clinical characterization of human framework for testing the stress-diathesis model of suicidal behavior. The CEC identified and recruits patients with MDE, BPD, and Schizophrenia across the life cycle (and post-mortem). Normal volunteers are recruited to provide normative values on the clinical and neurobiological measures used and to establish psychometric properties of measures in a non-pathological population. The CEC utilizes a core of clinical/neuropsychological instruments covering major risk factor domains for suicidal behavior, and ensures uniformity of assessment domains and measures across the projects of the CCNMD. These assessments include Axis I and II diagnostic interviews, measures of state and trait-related risk factors, neuropsychological assessment, measures of suicidal behavior, demographic history, life events, social functioning, family psychiatric history. Assessments are performed at intake, at time of biological procedures, at discharge, at 3 month, 1 and 2 year follow-up. The CEC investigates, develops and tests new assessment procedures to address current and future needs in the field of suicide research, and regularly reviews the reliability and validity of instruments. The CEC ensures the quality of clinical assessments through inter-rater reliability rounds using live or taped interviews. On all measures, our faculty provides consultation to investigators in research methodology and result interpretation. The CEC faculty provides consultation to investigators in research methodology and result interpretation. The CEC has successfully recruited and followed adequate members of life subjects in the proposed diagnostic and age categories. The training and reliability of all CCNMD raters is coordinated by the CEC. The CEC works with SCC staff in developing forms, data management procedures and in generating reliability statistics The CEC coordinates with the BIC regarding recruitment, interviewing, control matching and subject flow. The CEC obtains the blood and cerebrospinal fluid from subjects to be analyzed by the CLC. The CEC interfaces with the Administrative Core regarding recruitment of new staff and maintenance of a central database of all CEC manuscripts. The CEC coordinates all diagnostic consensus conferences.