Core--Clinical evaluation

核心--临床评价

• 批准号: 6643687
• 负责人: HAROLD A. SACKEIM
• 金额: $ 17.72万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6643687
• 关键词: biomedical facility; clinical research; human subject; medical outreach /case finding; patient /disease registry; suicide

The Clinical Evaluation Core's goals are to: (1) recruit, characterize, and follow all human subjects participating in projects #2-7 of the CCNMD (2) develop and maintain state-of-the-art methods for clinical characterization of human framework for testing the stress-diathesis model of suicidal behavior. The CEC identified and recruits patients with MDE, BPD, and Schizophrenia across the life cycle (and post-mortem). Normal volunteers are recruited to provide normative values on the clinical and neurobiological measures used and to establish psychometric properties of measures in a non-pathological population. The CEC utilizes a core of clinical/neuropsychological instruments covering major risk factor domains for suicidal behavior, and ensures uniformity of assessment domains and measures across the projects of the CCNMD. These assessments include Axis I and II diagnostic interviews, measures of state and trait-related risk factors, neuropsychological assessment, measures of suicidal behavior, demographic history, life events, social functioning, family psychiatric history. Assessments are performed at intake, at time of biological procedures, at discharge, at 3 month, 1 and 2 year follow-up. The CEC investigates, develops and tests new assessment procedures to address current and future needs in the field of suicide research, and regularly reviews the reliability and validity of instruments. The CEC ensures the quality of clinical assessments through inter-rater reliability rounds using live or taped interviews. On all measures, our faculty provides consultation to investigators in research methodology and result interpretation. The CEC faculty provides consultation to investigators in research methodology and result interpretation. The CEC has successfully recruited and followed adequate members of life subjects in the proposed diagnostic and age categories. The training and reliability of all CCNMD raters is coordinated by the CEC. The CEC works with SCC staff in developing forms, data management procedures and in generating reliability statistics The CEC coordinates with the BIC regarding recruitment, interviewing, control matching and subject flow. The CEC obtains the blood and cerebrospinal fluid from subjects to be analyzed by the CLC. The CEC interfaces with the Administrative Core regarding recruitment of new staff and maintenance of a central database of all CEC manuscripts. The CEC coordinates all diagnostic consensus conferences.

临床评估核心的目标是：(1) 招募、表征和 关注参与 CCNMD 项目 #2-7 的所有人类受试者 (2) 开发和维护最先进的临床方法 用于测试压力素质的人体框架的表征 自杀行为模型。 CEC 确定并招募患有以下疾病的患者： MDE、BPD 和精神分裂症贯穿整个生命周期（和死后）。 招募普通志愿者来提供关于 使用临床和神经生物学措施并建立心理测量学 非病态人群的测量特性。 CEC 利用 涵盖主要风险的临床/神经心理学核心工具 自杀行为的因素域，并确保自杀行为的一致性 CCNMD 各个项目的评估领域和措施。 这些评估包括轴 I 和轴 II 诊断访谈、措施 状态和特质相关的危险因素、神经心理学评估、 自杀行为、人口历史、生活事件、社会 功能正常，家族精神病史。评估进行于 摄入量、生物手术时、出院时、第 3 个月、第 1 个月和第 2 个月 年随访。 CEC 调查、开发和测试新评估 解决自杀领域当前和未来需求的程序 研究，并定期审查仪器的可靠性和有效性。 CEC 通过评估者间确保临床评估的质量 使用现场或录音采访进行可靠性调查。在所有措施上，我们 教师为研究人员提供研究方法方面的咨询 和结果解释。 CEC教师提供咨询 研究方法和结果解释的研究者。中委会 已成功招募并跟踪足够的生活受试者成员 在建议的诊断和年龄类别中。培训和可靠性 所有 CCNMD 评估者的评估均由 CEC 协调。 CEC 与 SCC 员工负责开发表格、数据管理程序和 生成可靠性统计数据 CEC 与 BIC 协调 关于招聘、面试、控制匹配和主题流程。 CEC从受试者身上获取血液和脑脊液 由 CLC 分析。 CEC 与管理核心接口 关于招聘新工作人员和维护中央数据库 所有 CEC 手稿。 CEC 协调所有诊断共识 会议。