Endocrinological aspects of behavioral dysregulation during early development

描述：这项建议试图在100名6个月到2岁的婴儿和150名6、15和24个月大的横断面队列中检查生物、心理和社会功能的相互关系。研究这些队列的目的是描述神经内分泌措施，这些措施与婴儿的特征有关，可能使他们容易出现心理健康问题。受试者和他们的照顾者使他们容易出现心理健康问题。受试者和他们的照顾者将使用唾液皮质醇和实验室应激程序(母亲分离和母亲仍然面对)进行评估，试图描述和解释照顾者特征与婴儿调节特征(睡眠、喂养、喂养和哭泣)的相互作用，这些特征定义了调节失调的结构。此外，这项研究试图探索儿童昼夜节律的建立和可预测性，以此作为稳定的基础皮质醇水平的先兆，这表明LHPA轴的应激反应较少。

Description: This proposal seeks to examine the interrelations of biological, psychological, and social functioning in a cohort of 100 infants from 6 months to 2 years, and a second cross-sectional cohort of 150 subjects at 6, 15, and 24 months of age. The purpose of studying these cohorts is to delineate neuroendocrine measures that are linked to characteristics of infants that may predispose them to mental health problems. The subjects and their caretakers predispose them to mental health problems. The subjects and their caretakers will be assessed using salivary cortisol and a laboratory stress procedure (maternal separation and maternal still face) in an attempt to describe and explain the interaction of caregiver characteristics with infant regulatory features (sleeping, feeding, feeding, and crying) that define a construct of dysregulation. In addition, the study seeks to explore the establishment and predictability of circadian rhythms in children as an antecedent to stable basal cortisol levels indicative of a "less reactive" stress LHPA axis.