Endocrinological aspects of behavioral dysregulation during early development

描述：本研究旨在研究100名6个月至2岁婴儿的生理、心理和社会功能的相互关系，以及第二个横断面队列的150名6、15和24个月大的婴儿。研究这些队列的目的是描述与婴儿特征相关的神经内分泌测量，这些特征可能使他们易患心理健康问题。受试者和他们的看护人使他们容易出现心理健康问题。受试者和他们的看护人将使用唾液皮质醇和实验室应激程序（母亲分离和母亲仍然面对）进行评估，试图描述和解释看护人特征与婴儿调节特征（睡眠、喂养、喂养和哭泣）的相互作用，这些特征定义了调节失调的结构。此外，该研究试图探索儿童昼夜节律的建立和可预测性，作为稳定的基础皮质醇水平的前提，表明应激LHPA轴的“反应性较低”。

Description: This proposal seeks to examine the interrelations of biological, psychological, and social functioning in a cohort of 100 infants from 6 months to 2 years, and a second cross-sectional cohort of 150 subjects at 6, 15, and 24 months of age. The purpose of studying these cohorts is to delineate neuroendocrine measures that are linked to characteristics of infants that may predispose them to mental health problems. The subjects and their caretakers predispose them to mental health problems. The subjects and their caretakers will be assessed using salivary cortisol and a laboratory stress procedure (maternal separation and maternal still face) in an attempt to describe and explain the interaction of caregiver characteristics with infant regulatory features (sleeping, feeding, feeding, and crying) that define a construct of dysregulation. In addition, the study seeks to explore the establishment and predictability of circadian rhythms in children as an antecedent to stable basal cortisol levels indicative of a "less reactive" stress LHPA axis.