DEMOGRAPHIC ANALYSIS OF DETERMINANTS OF LONGEVITY IN CHINA

中国长寿决定因素的人口统计分析

• 批准号: 6411202
• 负责人: zeng yi
• 金额: $ 38.95万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-15 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6411202
• 关键词: China; clinical research; computers; environmental stressor; genetic susceptibility; human mortality; human old age (65+); human population study; human subject; human tissue; human very old age (85+); information systems; longevity; siblings

DESCRIPTION: (adapted from the application): The general goal of this project is to shed new light on both the non-genetic and genetic determinants of exceptional longevity and oldest-old mortality. In 1998, with NIA research support, extensive questionnaire data as well as DNA was gathered on 3000 centenarians and more than 7000 octogenarians and nonagenarians in China. The sample includes about 1500 groups of two or more siblings. The survey was designed such that all centenarians in half of the .administrative districts of the predominantly Hart provinces of China were interviewed. Here two follow-up surveys are proposed, one in the year 2000 and one in 2002. Survivors from the 1998 survey will be re-interviewed in 2000 and survivors from the 2000 survey will be re-interviewed in 2002. Data on date and cause of death will be gathered for those who die between the waves of interviews. All new centenarians in the administrative districts surveyed will be interviewed in 2000 and 2002. In addkion, people who reach ages 80 and 81 in the year 2000 and in the year 2002 will be added to the sample. Finally, those octogenarians and nonagenarians who die between the survey waves will be replaced by new people of rnatched age and sex. Over the three waves of the survey, questionnaire data and DNA will be gathered on nearly 7000 centenarians and more than 11,000 octogenarians and nonagenanans, including more than 3000 groups of 2 or more siblings. Furthermore, data on date and cause of death will be collected on about 10,000 oldest-old individuals in the survey. The 1998 survey alone provides valuable data. However, cross-sectional data are of limited value because no information is available about mortality. This restriction is particularly severe for a study of the determinants of survival and longevity. The two proposed follow-up studies will provide longitudinal data on survival as well as data on changes in status, including health status. The study as a whole will be by far the largest study of the health and other characteristics of the oldest-old and of the survival of the oldest-old.

描述：（改编自申请）：该项目的总体目标是揭示异常长寿和最长寿死亡率的非遗传和遗传决定因素。1998年，在NIA的研究支持下，对中国3000名百岁老人和7000多名八十多岁和九十多岁老人进行了广泛的问卷调查和DNA数据收集。样本包括大约1500个两个或更多兄弟姐妹的群体。这项调查是这样设计的，所有的百岁老人在一半的。访谈对象主要是中国哈特省的行政区域。这里提出了两次后续调查，一次在2000年，一次在2002年。1998年调查的幸存者将于2000年再次接受访问，2000年调查的幸存者将于2002年再次接受访问。将收集在两次访谈之间死亡的人的死亡日期和死因数据。将在2000年和2002年对所有被调查行政区域的新百岁老人进行调查。此外，在2000年和2002年分别达到80岁和81岁的人也将被加入到样本中。最后，在调查期间死亡的80多岁和90多岁老人将被年龄和性别相近的新人所取代。在三波调查中，将收集近7000名百岁老人和1.1万多名80多岁和90多岁老人的问卷数据和DNA，其中包括3000多组2个或更多的兄弟姐妹。此外，还将收集调查中约1万名老年人的死亡日期和死因数据。仅1998年的调查就提供了有价值的数据。然而，横断面数据的价值有限，因为没有关于死亡率的信息。这种限制对于研究生存和长寿的决定因素尤其严重。拟议的两项后续研究将提供关于生存的纵向数据以及关于状况变化（包括健康状况）的数据。总的来说，这项研究将是迄今为止对老年人的健康和其他特征以及老年人的生存进行的最大规模的研究。