DEMOGRAPHIC ANALYSIS OF DETERMINANTS OF LONGEVITY IN CHINA

中国长寿决定因素的人口统计分析

• 批准号: 6563281
• 负责人: zeng yi
• 金额: $ 17.85万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6563281
• 关键词: China; clinical research; computers; environmental stressor; genetic susceptibility; human mortality; human old age (65+); human population study; human subject; human tissue; human very old age (85+); information systems; longevity; siblings

Abstract: DESCRIPTION: (adapted from the application): The general goal of this project is to shed new light on both the non-genetic and genetic determinants of exceptional longevity and oldest-old mortality. In 1998, with NIA research support, extensive questionnaire data as well as DNA was gathered on 3000 centenarians and more than 7000 octogenarians and nonagenarians in China. The sample includes about 1500 groups of two or more siblings. The survey was designed such that all centenarians in half of the .administrative districts of the predominantly Hart provinces of China were interviewed. Here two follow-up surveys are proposed, one in the year 2000 and one in 2002. Survivors from the 1998 survey will be re-interviewed in 2000 and survivors from the 2000 survey will be re-interviewed in 2002. Data on date and cause of death will be gathered for those who die between the waves of interviews. All new centenarians in the administrative districts surveyed will be interviewed in 2000 and 2002. In addkion, people who reach ages 80 and 81 in the year 2000 and in the year 2002 will be added to the sample. Finally, those octogenarians and nonagenarians who die between the survey waves will be replaced by new people of rnatched age and sex. Over the three waves of the survey, questionnaire data and DNA will be gathered on nearly 7000 centenarians and more than 11,000 octogenarians and nonagenanans, including more than 3000 groups of 2 or more siblings. Furthermore, data on date and cause of death will be collected on about 10,000 oldest-old individuals in the survey. The 1998 survey alone provides valuable data. However, cross-sectional data are of limited value because no information is available about mortality. This restriction is particularly severe for a study of the determinants of survival and longevity. The two proposed follow-up studies will provide longitudinal data on survival as well as data on changes in status, including health status. The study as a whole will be by far the largest study of the health and other characteristics of the oldest-old and of the survival of the oldest-old.

摘要：产品说明：（改编自应用程序）：该项目的总体目标是揭示特别长寿和高龄老人死亡率的非遗传和遗传决定因素。 1998年，在NIA的研究支持下，收集了中国3000名百岁老人和7000多名百岁老人和九十岁老人的广泛问卷数据以及DNA。 样本包括大约1500组两个或更多的兄弟姐妹。这项调查的目的是访问中国主要哈特省一半行政区的所有百岁老人。 在此建议进行两次后续调查，一次在2000年，一次在2002年。1998年调查的幸存者将于2000年再次接受访谈，2000年调查的幸存者将于2002年再次接受访谈。 将为那些在两次采访之间死亡的人收集死亡日期和死因的数据。2000年和2002年将对所调查行政区的所有新百岁老人进行面谈。在addkion，2000年和2002年达到80岁和81岁的人将被加入样本。最后，那些在调查波之间死亡的老年人和九十岁的人将被年龄和性别匹配的新人所取代。 在三波调查中，将收集近7000名百岁老人和11,000多名百岁老人和90多岁老人的问卷数据和DNA，其中包括3000多组2个或更多兄弟姐妹。此外，调查亦会收集约一万名高龄人士的死亡日期及死因资料。仅1998年的调查就提供了宝贵的数据。然而，由于没有关于死亡率的资料，因此，横截面数据的价值有限。这一限制对于研究生存和寿命的决定因素尤为严重。两项拟议的后续研究将提供关于生存的纵向数据以及关于状况变化的数据，包括健康状况。这项研究作为一个整体，将是迄今为止对最高龄老人的健康和其他特点以及最高龄老人的生存情况进行的最大规模的研究。