DEMOGRAPHIC ANALYSIS OF DETERMINANTS OF LONGEVITY IN CHINA

摘要：描述：(改编自本申请)：该项目的总体目标是阐明异常长寿和高龄死亡率的非遗传和遗传决定因素。1998年，在国家海洋局的研究支持下，收集了中国3000名百岁老人和7000多名八旬和非老年老人的问卷数据和DNA。样本包括大约1500组，每组两个或更多个兄弟姐妹。这项调查的目的是访问以哈特为主的中国省一半行政区的所有百岁老人。这里建议进行两次后续调查，一次是在2000年，一次是在2002年。1998年调查的幸存者将于2000年重新接受采访，2000年调查的幸存者将于2002年再次接受采访。在一波又一波的采访期间，将为那些死亡的人收集死亡日期和死因的数据。接受调查的行政区的所有新百岁老人将在2000年和2002年接受访问。在addkion，2000年和2002年达到80岁和81岁的人将被添加到样本中。最后，那些在调查浪潮之间死亡的八旬老人和非老年人将被新的年龄和性别抢夺的人取代。在这三波调查中，将收集近7000名百岁老人、11000多名八旬老人和八岁以上老人的问卷数据和DNA，其中包括3000多组2人或更多的兄弟姐妹。此外，调查中将收集约1万名年龄最大的老年人的死亡日期和死因数据。仅1998年的调查就提供了宝贵的数据。然而，横断面数据的价值有限，因为没有关于死亡率的信息。这一限制对于研究生存和长寿的决定因素尤其严格。两项拟议的后续研究将提供关于生存的纵向数据以及关于状况变化的数据，包括健康状况。作为一个整体，这项研究将是迄今为止规模最大的关于最年长老年人的健康和其他特征以及最年长老年人生存情况的研究。

Abstract: DESCRIPTION: (adapted from the application): The general goal of this project is to shed new light on both the non-genetic and genetic determinants of exceptional longevity and oldest-old mortality. In 1998, with NIA research support, extensive questionnaire data as well as DNA was gathered on 3000 centenarians and more than 7000 octogenarians and nonagenarians in China. The sample includes about 1500 groups of two or more siblings. The survey was designed such that all centenarians in half of the .administrative districts of the predominantly Hart provinces of China were interviewed. Here two follow-up surveys are proposed, one in the year 2000 and one in 2002. Survivors from the 1998 survey will be re-interviewed in 2000 and survivors from the 2000 survey will be re-interviewed in 2002. Data on date and cause of death will be gathered for those who die between the waves of interviews. All new centenarians in the administrative districts surveyed will be interviewed in 2000 and 2002. In addkion, people who reach ages 80 and 81 in the year 2000 and in the year 2002 will be added to the sample. Finally, those octogenarians and nonagenarians who die between the survey waves will be replaced by new people of rnatched age and sex. Over the three waves of the survey, questionnaire data and DNA will be gathered on nearly 7000 centenarians and more than 11,000 octogenarians and nonagenanans, including more than 3000 groups of 2 or more siblings. Furthermore, data on date and cause of death will be collected on about 10,000 oldest-old individuals in the survey. The 1998 survey alone provides valuable data. However, cross-sectional data are of limited value because no information is available about mortality. This restriction is particularly severe for a study of the determinants of survival and longevity. The two proposed follow-up studies will provide longitudinal data on survival as well as data on changes in status, including health status. The study as a whole will be by far the largest study of the health and other characteristics of the oldest-old and of the survival of the oldest-old.