SUBCLINICAL CARDIOVASCULAR DISEASE STUDY

MESA 是一项为期 10 年的观察性研究，研究对象是亚临床心血管疾病（在产生临床体征和症状之前通过非侵入性方式检测到的疾病）的特征以及预测临床明显心血管疾病进展和亚临床疾病本身进展的风险因素，研究对象为 6,500 名年龄在 45-84 岁之间的男性和女性，具有代表性的多样化人群样本。该群体中大约 40% 是白人，30% 是非洲裔美国人，20% 是西班牙裔美国人，10% 是华裔美国人。 该队列将从六个现场中心招募，并根据各种亚临床心血管疾病指标、标准冠状动脉危险因素、社会人口因素、生活方式因素和社会心理因素进行表征。 血液样本将进行假定的生化危险因素分析，并储存用于病例对照研究。 将提取 DNA 并使淋巴细胞永生化，以研究候选基因并可能进行全基因组扫描。 计划进行四次临床检查，间隔 18-24 个月。将跟踪参与者以确定和描述心血管疾病事件和所接受的干预措施。

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84. Approximately 40 percent of the cohort will be white, 30 percent African-American, 20 percent Hispanic, and 10 percent Chinese-American. The cohort will be recruited from six Field Centers and characterized with respect to a variety of subclinical cardiovascular disease measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for case-control studies. DNA will be extracted and lymphocytes immortalized for study of candidate genes and possibly genome-wide scanning. Four clinical examinations, 18-24 months apart, are planned. Participants will be followed for identification and characterization of cardiovascular disease events and interventions received.