SUBCLINICAL CARDIOVASCULAR DISEASE STUDY

梅萨是一项为期10年的亚临床心血管疾病（在产生临床体征和症状之前以非侵入性方式检测到的疾病）特征和风险因素的观察性研究，这些风险因素可预测临床上明显的心血管疾病的进展，并预测亚临床疾病本身的进展，在6，500名45-84岁男性和女性的多样化和代表性人群样本中进行。大约40%的人群将是白色，30%的非洲裔美国人，20%的西班牙裔美国人和10%的华裔美国人。 该队列将从6个现场中心招募，并在各种亚临床心血管疾病指标、标准冠状动脉风险因素、社会人口因素、生活方式因素和心理社会因素方面进行表征。 将对血液样本进行推定生化风险因素分析，并储存用于病例对照研究。 将提取DNA并使淋巴细胞永生化，用于候选基因的研究和可能的全基因组扫描。 计划进行四次临床检查，间隔18-24个月。将对受试者进行随访，以识别和描述心血管疾病事件和接受的干预措施。

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84. Approximately 40 percent of the cohort will be white, 30 percent African-American, 20 percent Hispanic, and 10 percent Chinese-American. The cohort will be recruited from six Field Centers and characterized with respect to a variety of subclinical cardiovascular disease measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for case-control studies. DNA will be extracted and lymphocytes immortalized for study of candidate genes and possibly genome-wide scanning. Four clinical examinations, 18-24 months apart, are planned. Participants will be followed for identification and characterization of cardiovascular disease events and interventions received.