SUBCLINICAL CARDIOVASCULAR DISEASE STUDY

亚临床心血管疾病研究

• 批准号: 6370030
• 负责人: RUSSELL P TRACY
• 金额: --
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2009-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6370030
• 关键词: African American; Chinese American; Hispanic Americans; atherosclerosis; cardiovascular disorder epidemiology; caucasian American; clinical chemistry; clinical research; coronary disorder; disease /disorder proneness /risk; early diagnosis; human middle age (35-64); human old age (65+); human subject; mass screening; noninvasive diagnosis; prognosis; racial /ethnic difference

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84. Approximately 40 percent of the cohort will be white, 30 percent African-American, 20 percent Hispanic, and 10 percent Chinese-American. The cohort will be recruited from six Field Centers and characterized with respect to a variety of subclinical cardiovascular disease measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for case-control studies. DNA will be extracted and lymphocytes immortalized for study of candidate genes and possibly genome-wide scanning. Four clinical examinations, 18-24 months apart, are planned. Participants will be followed for identification and characterization of cardiovascular disease events and interventions received.

MESA是一项为期10年的观察性研究，对亚临床心血管疾病(在产生临床体征和症状之前非侵入性检测到的疾病)和风险因素的特征进行观察，这些风险因素预测发展为临床明显的心血管疾病，并预测亚临床疾病本身的进展，研究对象为年龄在45-84岁的6500名具有代表性的男性和女性。大约40%的人将是白人，30%的非裔美国人，20%的西班牙裔和10%的华裔美国人。该队列将从六个现场中心招募，并针对各种亚临床心血管疾病措施、标准冠状动脉风险因素、社会人口因素、生活方式因素和心理社会因素进行特征分析。血液样本将被检测出可能的生化危险因素，并储存起来用于病例对照研究。DNA将被提取，淋巴细胞将永生，用于研究候选基因，并可能进行全基因组扫描。计划进行四次临床检查，间隔18-24个月。将对参与者进行跟踪，以确定和描述心血管疾病事件和接受的干预措施。

项目成果

Differences in the incidence of congestive heart failure by ethnicity: the multi-ethnic study of atherosclerosis.

• DOI: 10.1001/archinte.168.19.2138
• 发表时间: 2008-10-27
• 期刊: ARCHIVES OF INTERNAL MEDICINE
• 作者: Bahrarni, Hossein;Kronmal, Richard;Bluemke, David A.;Olson, Jean;Shea, Steven;Liu, Kiang;Burke, Gregory L.;Lima, Joao A. C.
• 通讯作者: Lima, Joao A. C.

Combining data from primary and ancillary surveys to assess the association between neighborhood-level characteristics and health outcomes: the Multi-Ethnic Study of Artherosclerosis.

结合主要和辅助调查的数据来评估社区特征与健康结果之间的关联：动脉粥样硬化的多种族研究。

• DOI: 10.1002/sim.3384
• 发表时间: 2008
• 期刊: Statistics in medicine
• 影响因子: 2
• 作者: Sánchez,BN;Raghunathan,TE;DiezRoux,AV;Zhu,Y;Lee,O
• 通讯作者: Lee,O