GIVEN BUILDING ANIMAL FACILITY UPGRADE

鉴于建筑动物设施升级

• 批准号: 6760703
• 负责人: RUSSELL P TRACY
• 金额: $ 52.06万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-29 至 2005-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6760703
• 关键词: air filtration; animal care; animal colony; biomedical facility; building /facility design /renovation; laboratory mouse

DESCRIPTION (provided by applicant): The University of Vermont (UVM) is requesting funds to upgrade the existing animal facility space located in the basement of the College of Medicine Given Building at the UVM Central Campus in Burlington, Vermont. A critical need has been identified to expand the capability of the existing facilities housing research animals. The production of genetically engineered mice is now occurring in semi-rigid isolators in a newly commissioned research building attached to the 40-year-old Given Building. The Given facility continues to contain a conventional animal colony holding facility; this capacity is required for growth of the research enterprise. In order to convert this conventional facility into a serviceable facility providing barrier at the cage level for rodents, it must be upgraded. In particular, this is required for the elimination of ongoing murine viral disease outbreaks in the research rodent holding operations. The requested funds will be used to purchase: a) upgraded mobile high density caging systems, b) filtered air bedding disposal systems, and c) laminar flow HEPA filtered air workbench hoods. Ten conventional holding rooms for mice will be converted cage level holding rooms for mice. This has the added advantage of doubling the capacity of each room as the proposed racks hold 140 cages while the existing open racks only hold a maximum of 70 cages per rack. Both the tunnel type cage washer and the rack washer have been replaced within the last five years and are not being used to capacity at this time. Expansion requires investment and the UVM administration is committed to continuing the support of this valuable research resource. Research supported by this centralized animal facility annually totals over $20,000,000. The results of previous studies using animals at UVM have been applied to many of the clinical medical and diagnostic techniques currently in use at the UVM affiliated Fletcher Allen Health Care and in other major medical treatment facilities around the world.

描述（由申请人提供）： 佛蒙特大学 (UVM) 正在申请资金来升级位于佛蒙特州伯灵顿 UVM 中心校区医学院大楼地下室的现有动物设施空间。现已确定迫切需要扩大现有研究动物饲养设施的能力。 基因工程小鼠的生产目前正在一座新投入使用的研究大楼的半刚性隔离器中进行，该大楼附属于已有 40 年历史的吉文大楼。吉文设施继续包含传统的动物群体饲养设施；研究企业的发展需要这种能力。为了将这种传统设施转变为可使用的设施，为啮齿动物提供笼子水平的屏障，必须对其进行升级。特别是，这是消除研究啮齿动物饲养场所中持续发生的鼠病毒性疾病爆发所必需的。所申请的资金将用于购买：a）升级的移动高密度笼式系统，b）过滤空气垫料处理系统，以及c）层流HEPA过滤空气工作台罩。十个传统的小鼠饲养室将改建为笼式小鼠饲养室。这还有一个额外的优点，即每个房间的容量加倍，因为拟议的机架可容纳 140 个笼子，而现有的开放式机架每个机架最多只能容纳 70 个笼子。隧道式笼式清洗机和架式清洗机均在过去五年内更换，目前尚未满负荷使用。 扩张需要投资，UVM 管理部门致力于继续支持这一宝贵的研究资源。该集中动物设施每年支持的研究总额超过 20,000,000 美元。 UVM 之前使用动物进行的研究结果已应用于 UVM 附属弗莱彻艾伦医疗保健中心和世界各地其他主要医疗机构目前使用的许多临床医疗和诊断技术。