GIVEN BUILDING ANIMAL FACILITY UPGRADE

描述（由申请人提供）： 佛蒙特大学（UVM）正在申请资金，以升级位于佛蒙特州伯灵顿UVM中央校区医学院给定大楼地下室的现有动物设施空间。已确定迫切需要扩大现有设施的能力，住房研究动物。 基因工程小鼠的生产现在正在一个新委托的研究大楼的半刚性隔离器中进行，该研究大楼与40岁的Given大楼相连。Given设施继续包含一个传统的动物群体保存设施;这种能力是研究企业发展所必需的。为了把这个传统设施改造成一个可以在笼层为啮齿动物提供屏障的可用设施，必须将其升级。特别是，这是需要消除正在进行的鼠病毒性疾病爆发的研究啮齿动物控股业务。申请的资金将用于购买：a）升级的移动的高密度笼系统，B）过滤空气垫料处理系统，以及c）层流HEPA过滤空气工作台罩。将10个常规小鼠饲养室转换为小鼠笼级饲养室。这有一个额外的好处，即每个房间的容量增加了一倍，因为拟议的机架可容纳140个笼子，而现有的开放式机架每个机架最多只能容纳70个笼子。隧道式笼式垫圈和机架式垫圈在过去五年内均已更换，目前尚未达到最大容量。 扩展需要投资，UVM管理部门致力于继续支持这一宝贵的研究资源。这个集中的动物设施每年支持的研究总额超过2000万美元。先前在UVM使用动物的研究结果已应用于UVM附属弗莱彻艾伦医疗保健和世界各地其他主要医疗机构目前使用的许多临床医疗和诊断技术。

DESCRIPTION (provided by applicant): The University of Vermont (UVM) is requesting funds to upgrade the existing animal facility space located in the basement of the College of Medicine Given Building at the UVM Central Campus in Burlington, Vermont. A critical need has been identified to expand the capability of the existing facilities housing research animals. The production of genetically engineered mice is now occurring in semi-rigid isolators in a newly commissioned research building attached to the 40-year-old Given Building. The Given facility continues to contain a conventional animal colony holding facility; this capacity is required for growth of the research enterprise. In order to convert this conventional facility into a serviceable facility providing barrier at the cage level for rodents, it must be upgraded. In particular, this is required for the elimination of ongoing murine viral disease outbreaks in the research rodent holding operations. The requested funds will be used to purchase: a) upgraded mobile high density caging systems, b) filtered air bedding disposal systems, and c) laminar flow HEPA filtered air workbench hoods. Ten conventional holding rooms for mice will be converted cage level holding rooms for mice. This has the added advantage of doubling the capacity of each room as the proposed racks hold 140 cages while the existing open racks only hold a maximum of 70 cages per rack. Both the tunnel type cage washer and the rack washer have been replaced within the last five years and are not being used to capacity at this time. Expansion requires investment and the UVM administration is committed to continuing the support of this valuable research resource. Research supported by this centralized animal facility annually totals over $20,000,000. The results of previous studies using animals at UVM have been applied to many of the clinical medical and diagnostic techniques currently in use at the UVM affiliated Fletcher Allen Health Care and in other major medical treatment facilities around the world.