MUSCLE METABOLISM AND EFFECT IN BODY WEIGHT

骨关节炎(OA)是一种软骨退行性疾病，导致 导致组织失去正常的功能。骨性关节炎的早期退变 软骨与蛋白多糖(PG)的丢失有关。我们有 最近发现有可能测量软骨中PG的丢失 关节核磁共振~(23)Na间接测定钠 体内软骨和体外软骨。我们想要进一步描述这一点 根据环境将钠分为两种。 在生物组织中存在着游离态和结合态的钠。 游离钠通常是各向同性的，而结合钠通常是各向同性的。 经历各向异性运动，因此~(23)Na核磁共振信号衰减 在这些组织中是双指数的。我们正试图准确地 用~(23)Na测定体模和软骨中结合钠的含量 多量子滤波(MQF)核磁共振。通过测量平衡 SQ和MQF信号的磁化将使人们能够量化 钠的成键分数。我们已经在幻影中测量了这一点 目前正在对软骨进行测量。

Osteoarthritis (OA) is a cartilage degenerative disease that leads to loss of proper function of the tissue. Early degeneration of OA cartilage is associated with the loss of proteoglycans (PG). We have recently shown that it is possible to measure PG loss in cartilage indirectly by quantitation of sodium by 23Na MRI of articular cartilage in-vivo and in-vitro. We want to further characterize this sodium by classifying it into two species based on their environments. In biological tissues there exists free and bound sodium fractions. The free sodium is usually in isotropic motion whereas bound sodium undergoes anisotropic motion and hence the 23Na NMR signal decay is biexponential in these tissues. We are attempting to precisely quantify the amount of bound sodium in phantoms and cartilage by 23Na Multiple Quantum Filtered (MQF) NMR. By measuring the equilibrium magnetization by both SQ and MQF signals will enable one to quantitate bond fraction of sodium. We ha ve measured this in phantoms and currently in the process of measuring in cartilage.