IS MUSCLE METABOLISM AFFECTED BY CHANGES IN BODY WEIGHT?
IS MUSCLE METABOLISM AFFECTED BY CHANGES IN BODY WEIGHT?
批准号:
6121067
负责人:
MICHAEL ROSENBAUM
金额:
$1.35万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-09-30 至 1999-09-29
中文摘要
美国大约34%的成年人都是这样
英文摘要
Approximately 34% of the adult population in the United States is
overweight. Several investigators have postulated that the difficulty
to maintain weight loss is linked to changes in skeletal muscle
metabolism with weight perturbations. We are investigating this
hypothesis by measuring the basal phosphate content and the in vivo
oxidative capacity based on the PCr resynthesis rate (kPCr) after
larger weight alterations in both obese and non-obese. Initial
analysis of MRS measurements shows that a reduction in body weight is
associated with an increase in the Pi content. In both the obese and
non-obese a 10% decrease in body weight was associated with a 16% and
12% increase in basal Pi content respectively. Conversely, a 10%
increase in body weight in the non-obese resulted in a 6% decrease in
Pi content. The k Pcr(s-1) in the control group was shown to increase
with weight. The skeletal muscle of the control group becomes more
efficient at increased weight, and less efficient at lower weights.
The obese group showed different changes in skeletal muscle capacity
due to weight loss. The k Pcr at -20% was 2.45 as compared to 1.99 at
baseline. The value at -10% was unchanged from baseline at 1.95.
This suggests that in the obese population a decrease in weight was
accompanied by an increase in the skeletal muscle oxidative capacity.
Both the changes in kPCr and basal Pi content in the obese
group support the hypothesis that weight perturbations affect skeletal
muscle metabolism, with an increase in the oxidative capacity with
weight loss and a decrease in oxidative capacity with weight gain.
Analysis of basal Pi in the control group showed the same trend as the
obese group, but k PCr measurements did not agree. Confirmative
studies using in vitro biochemical measures of muscle biopsies and
whole body oxygen consumption measurements during low level exercise
are currently being performed. These data provide evidence that
metabolic alterations may contribute to the high recidivism of weight
increase after weight loss.
Future studies will focus on using a spectra localization
technique to look more specifically at the medial gastrocnemius at the
different stages of weight loss and gain. Localized baseline
measurements have been performed on one subject to date.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
EFFECTS OF LOW-DOSE LEPTIN ON THE METABOLIC/BEHAVIORAL PHENOTYPES
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批准号:7205919
-
项目类别:
-
资助金额:$23.81万
-
财政年份:2005
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
ENERGY HOMEOSTASIS IN HUMAN OBESITY
-
批准号:6977468
-
项目类别:
-
资助金额:$0.68万
-
财政年份:2004
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
Effects of Low-Dose Leptin on the Metabolic/Behavioral Phenotypes
-
批准号:7045039
-
项目类别:
-
资助金额:$12.72万
-
财政年份:2003
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
MUSCLE METABOLISM AND EFFECT IN BODY WEIGHT
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批准号:6657664
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项目类别:
-
资助金额:$22.55万
-
财政年份:2002
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
MUSCLE METABOLISM AND EFFECT IN BODY WEIGHT
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批准号:6495473
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项目类别:
-
资助金额:$22.55万
-
财政年份:2001
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
SKELETAL MUSCLE PHYSIOLOGY IN HUMAN OBESITY
-
批准号:6567847
-
项目类别:
-
资助金额:$19.29万
-
财政年份:2001
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
SKELETAL MUSCLE PHYSIOLOGY IN HUMAN OBESITY
-
批准号:6468584
-
项目类别:
-
资助金额:$19.29万
-
财政年份:2000
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
MUSCLE METABOLISM AND EFFECT IN BODY WEIGHT
-
批准号:6349330
-
项目类别:
-
资助金额:$2.1万
-
财政年份:2000
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
IS MUSCLE METABOLISM AFFECTED BY CHANGES IN BODY WEIGHT?
-
批准号:6252181
-
项目类别:
-
资助金额:$1.94万
-
财政年份:1997
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
ONTOGENY AND MAINTENANCE OF REGIONAL FAT DISTRIBUTION
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批准号:3080893
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项目类别:
-
资助金额:$6.55万
-
财政年份:1991
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
ONTOGENY AND MAINTENANCE OF REGIONAL FAT DISTRIBUTION
-
批准号:2133614
-
项目类别:
-
资助金额:$9.0万
-
财政年份:1991
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
ONTOGENY AND MAINTENANCE OF REGIONAL FAT DISTRIBUTION
-
批准号:2133615
-
项目类别:
-
资助金额:$9.49万
-
财政年份:1991
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
ONTOGENY AND MAINTENANCE OF REGIONAL FAT DISTRIBUTION
-
批准号:3080894
-
项目类别:
-
资助金额:$6.8万
-
财政年份:1991
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
ONTOGENY AND MAINTENANCE OF REGIONAL FAT DISTRIBUTION
-
批准号:3080895
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项目类别:
-
资助金额:$9.0万
-
财政年份:1991
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
EFFECTS OF BODY WEIGHT ON CATECHOLAMINE RELEASE AND ACTIVITY
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批准号:5219579
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MICHAEL ROSENBAUM
-
依托单位:--
THE ONTOGENY AND MAINTENANCE OF REGIONAL FAT DISTRIBUTION
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批准号:3741556
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
THE ONTOGENY AND MAINTENANCE OF REGIONAL FAT DISTRIBUTION
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批准号:3763748
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:MICHAEL ROSENBAUM
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依托单位:
BLOOD GLUCOSE CHANGES ASSOCIATED WITH FEEDING
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批准号:3763784
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
THE ONTOGENY AND MAINTENANCE OF REGIONAL FAT DISTRIBUTION
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批准号:5219550
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:MICHAEL ROSENBAUM
-
依托单位:--
BLOOD GLUCOSE CHANGES ASSOCIATED WITH FEEDING IN HUMANS
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批准号:3741568
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项目类别:
-
资助金额:$0.0万
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财政年份:--
-
负责人:MICHAEL ROSENBAUM
-
依托单位:
海外基金