OSTEOARTHR: IN VIVO TRIPLE QUANTUM FILTERED TWISTED PROJECTION SODIUM MRI

OSTEOARTHR：体内三重量子过滤扭曲投影钠 MRI

• 批准号: 6495461
• 负责人: ARIJITT BORTHAKUR
• 金额: $ 22.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6495461
• 关键词: biomedical resource; female; human subject; lasers

Previous work in this laboratory has emphasized the use of frequency-domain measurements for optical imaging. We have now extended this work to include the analog of emission tomography with diffusing waves. In conventional emission tomography the spatial distribution of a radioactive source is imaged using a variant of standard tomographic image reconstruction. Here emission tomography refers to the reconstruction of a fluorescent source distribution which has been excited by a diffusing wave. In previous work we have developed a direct reconstruction algorithm for diffusive emission tomography. Briefly, the number density of a fluorescent source in a highly-scattering medium may be reconstructed by numerically solving an integral equation that relates the quantum efficiency of the exciting diffusing wave to the number density. We have demonstrated the experimental validation of this method in model systems whose optical properties are similar to those of biological tissue. Ultimately, this method could be applied to imaging tumors or other structures tagged by a fluorescent probe.

本实验室以前的工作强调使用 用于光学成像的频域测量。 我们现在已经 扩展这项工作，包括模拟发射断层扫描， 扩散波 在传统的发射断层扫描中， 放射源的分布使用以下的变型成像： 标准断层图像重建。 这里发射断层扫描 术语“重建”指荧光源分布的重建 它被扩散波激发。 在以前的工作中， 发展了一种直接重建扩散发射的算法 断层扫描 简而言之，荧光源在微阵列中的数量密度是指荧光源的数量密度。 高散射介质可以通过数值求解 一个积分方程，涉及量子效率的 激发扩散波达到数密度。 我们已经证明 该方法在模型系统中的实验验证， 光学性质与生物组织的光学性质相似。 最终，这种方法可以应用于成像肿瘤或其他 荧光探针标记的结构。