OSTEOARTHR: IN VIVO TRIPLE QUANTUM FILTERED TWISTED PROJECTION SODIUM MRI

本实验室以前的工作强调了使用 光学成像的频域测量。我们现在有了 将这项工作扩展到包括发射断层扫描的模拟 扩散的海浪。在传统的发射断层扫描中，空间 放射源的分布是使用变种的 标准层析图像重建。这里发射断层扫描 指的是重建荧光源的分布情况 它是由扩散波激发的。在以前的工作中，我们有 提出了一种扩散发射的直接重建算法 体层摄影术。简而言之，荧光源的数密度在一个 高散射介质可以通过数值求解来重建 与量子效率有关的积分方程式 激发扩散波到数密度。我们已经证明了 该方法在模型系统中的实验验证 光学特性与生物组织的光学特性相似。 最终，这种方法可以应用于肿瘤或其他疾病的成像 用荧光探头标记的结构。

Previous work in this laboratory has emphasized the use of frequency-domain measurements for optical imaging. We have now extended this work to include the analog of emission tomography with diffusing waves. In conventional emission tomography the spatial distribution of a radioactive source is imaged using a variant of standard tomographic image reconstruction. Here emission tomography refers to the reconstruction of a fluorescent source distribution which has been excited by a diffusing wave. In previous work we have developed a direct reconstruction algorithm for diffusive emission tomography. Briefly, the number density of a fluorescent source in a highly-scattering medium may be reconstructed by numerically solving an integral equation that relates the quantum efficiency of the exciting diffusing wave to the number density. We have demonstrated the experimental validation of this method in model systems whose optical properties are similar to those of biological tissue. Ultimately, this method could be applied to imaging tumors or other structures tagged by a fluorescent probe.