Long-Lasting Effects of Neonatal Pain on Nociception

描述：(申请人提供)动物和婴儿的不成熟神经系统具有特殊的可塑性。感觉不适当的短暂时期 在发育的关键时间窗内的输入可能会导致感官知觉的永久性变化。侵袭性和外科手术的影响 在婴儿期关于伤害性感觉发展的经验 令人惊讶的是被忽视了。我们对……的影响缺乏了解 童年的痛苦被强调为人类婴儿的频率 在童年时遇到疼痛，通常是由侵入性手术引起的， 手术和创伤。基于之前的研究和我们目前对 甚至成人的伤害性感受器系统的延展性也是可以预料的。 幼年动物的痛苦经历会对 成人对疼痛敏感。这些实验的目标是确定有多小 新生大鼠仔鼠炎症损伤对其机械性能的永久性影响 和热敏感度为成体，识别出最大值的临界窗口 易感性，并开始表征神经机制 疼痛敏感度的改变是其根本原因。我们的研究结果可能会 影响我们对疼痛发展的基本认识，并影响临床 婴儿疼痛的处理。

DESCRIPTION: (provided by applicant) The immature nervous systems of animals and infants are exceptionally malleable. Brief periods of inappropriate sensory input during critical time windows of development can lead to permanent alterations in sensory perception. The effects of invasive and surgical experiences during infancy on the development of nociception have been surprisingly neglected. Our lack of understanding about the effects of childhood pain is underscored by the frequency with which human infants encounter pain during childhood, commonly arising from invasive procedures, surgery and trauma. Based on previous research and our current appreciation of how malleable even the adult nociceptive system is, it would be anticipated that painful experiences in young animals would have a permanent effect on adult pain sensitivity. The goal of these experiments is to determine how minor inflammatory injury in newborn rat pups permanently influences their mechanical and thermal sensitivity as adults, to identify the critical window of maximum susceptibility, and to begin to characterize the neural mechanisms that underlie altered pain sensitivity. The results of our studies are likely to impact our basic understanding of pain development and influence the clinical management of pain in infants.