PSYCHOBIOLOGY OF SUICIDAL BEHAVIOR IN BORDERLINE PERSONALITY DISORDER

边缘性人格障碍自杀行为的心理生物学

• 批准号: 6304668
• 负责人: PAUL H SOLOFF
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304668
• 关键词: behavioral /social science research tag; borderline personality disorder; clinical research; fenfluramine; human subject; major depression; positron emission tomography; prolactin; psychobiology; serotonin; suicide

This is a first multidimensional study of the clinical, psychosocial and biological risk factors for suicide in patients with Borderline Personality Disorder (BPD), a disorder with a completed suicide rate of 3-9%. Forty patients with BPD will be compared to 40 patients with Major Depression (MDE) and 40 normal controls on measures of central serotonergic responsiveness, including prolactin response to challenging with d, 1, fenfluramine during PET scanning with FDG.

这是第一个多维度研究边缘型人格障碍（BPD）患者自杀的临床，心理社会和生物学风险因素，BPD是一种自杀率为3- 9%的疾病。将40例BPD患者与40例重度抑郁症（MDE）患者和40例正常对照进行比较，测量中枢神经系统的反应性，包括在FDG PET扫描期间对d，1，芬氟拉明激发的催乳素反应。