SEROTONIN, IMPULSIVITY, AND AGGRESSIVITY IN ADOLESCENT ALCOHOL USE DISORDERS

青少年酒精使用障碍中的血清素、冲动和攻击性

• 批准号: 6200892
• 负责人: PAUL H SOLOFF
• 金额: $ 22.14万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6200892
• 关键词: adolescence (12-20); aggression; alcoholism /alcohol abuse; attention deficit disorder; behavior test; behavioral /social science research tag; brain circulation; brain imaging /visualization /scanning; clinical research; comorbidity; conduct disorder; disease /disorder proneness /risk; fenfluramine; frontal lobe /cortex; functional magnetic resonance imaging; human subject; impulsive behavior; longitudinal human study; magnetic resonance imaging; neuroendocrine system; neuropharmacology; neuropsychological tests; psychobiology; serotonin; substance abuse related behavior; suicide; violence

A defect in central serotonergic regulation of impulse, affect, and behavior is associated with impulsive-aggressive behavior, personality disorder, affective disorder, suicidal behavior, and alcoholism in adults. This project addresses the relationship between diminished central serotonergic function in older adolescents (aged 16-19) and the diagnosis and severity of Alcohol Use Disorders, Conduct Disorder, impulsivity and aggressivity, suicidal, and violent behaviors. Serotonergic function is assessed through pharmacologic challenge with dl-fenfluramine (1 mg/kg) and the simultaneous measurement of neuroendocrine responses through blood sampling of prolactin and cortisol, and prefrontal cortical activation responses through fMRI techniques. Dynamic contrast fMRI study of hemodynamic responses in prefrontal cortex during activation with fenfluramine addresses the serotonergic responsiveness of an area intimately involved in self-regulation of impulse, affect, and behavior, while morphometric study by high resolution MRI may reveal structural differences. Eighty adolescents, half with Alcohol Use Disorders and half without will be studied in PAARC Years 06 and 07, with one and three year follow-ups to determine whether neuroendocrine and prefrontal cortical activation response variables predict adverse psychosocial outcomes. Adverse outcomes associated with these psychobiologic variables include: progression of severity of Alcohol Use Disorder, development of adult criteria for ASPD, affective disorders, suicidal, and violent behavior. This study will contribute to our understanding of the psychobiology of adolescent Alcohol Use Disorders and the identification of biologic risk factors that may predict long term adverse psychosocial consequences.

中枢神经系统对冲动、情感和 行为与冲动-攻击行为、个性 精神障碍、情感障碍、自杀行为和成人酗酒。 这个项目解决了减少的中央 老年青少年（16-19岁）的肾上腺素能功能及其诊断 酒精使用障碍，行为障碍，冲动和 攻击性自杀和暴力行为 血清素能功能是 通过dl-芬氟拉明（1 mg/kg）的药理学激发进行评估， 通过血液同时测量神经内分泌反应 催乳素和皮质醇的采样，以及前额叶皮层激活 通过fMRI技术。 动态对比fMRI研究 激活时前额叶皮层血流动力学反应 芬氟拉明解决了一个区域的肾上腺素能反应， 与冲动、情感和行为的自我调节密切相关， 而高分辨率MRI的形态学研究可能揭示结构 差异 80名青少年，一半患有酒精使用障碍，一半没有意愿 在PAARC 06年和07年进行研究，随访1年和3年， 确定神经内分泌和前额叶皮质激活 反应变量预测不良的心理社会结果。 不良结局 与这些心理生物学变量相关的包括： 酒精使用障碍的严重程度，成人ASPD标准的制定， 情感障碍自杀和暴力行为 这项研究将有助于我们理解的心理生物学的 青少年酒精使用障碍和生物风险的识别 可能预测长期不良心理社会后果的因素。