SEROTONIN, IMPULSIVITY, AND AGGRESSIVITY IN ADOLESCENT ALCOHOL USE DISORDERS

中枢5-羟色胺能调节冲动、情感和 行为与冲动--攻击性行为、个性 成人的精神障碍、情感障碍、自杀行为和酗酒。 该项目解决了缩小的中心 大龄青少年(16~19岁)的5-羟色胺能功能及其诊断 酒精使用障碍、品行障碍、冲动和 攻击性、自杀和暴力行为。5-羟色胺能功能是 通过dl-芬氟拉明(1 mg/kg)的药理激发和 经血同时测定神经内分泌反应 催乳素和皮质醇的取样和前额叶皮质的激活 通过功能磁共振成像技术进行反应。颅脑动态增强功能磁共振成像的研究 激活时前额叶皮质的血流动力学反应 芬氟拉明解决了区域的5-羟色胺能反应性 密切参与冲动、情感和行为的自我调节， 而高分辨率MRI的形态计量学研究可能揭示出 不同之处。 80名青少年，一半有酒精使用障碍，另一半没有意愿 将在PAARC 06年和07年进行研究，并进行一年和三年的跟踪 确定神经内分泌和前额叶皮质是否激活 反应变量预测不良的心理社会结果。不良后果 与这些心理生物学变量相关的包括：进展 酒精使用障碍的严重性，制定成人ASPD标准， 情感障碍、自杀和暴力行为。 这项研究将有助于我们理解精神分裂症的心理生物学。 青少年酒精使用障碍与生物风险识别 可能预测长期不良心理社会后果的因素。

A defect in central serotonergic regulation of impulse, affect, and behavior is associated with impulsive-aggressive behavior, personality disorder, affective disorder, suicidal behavior, and alcoholism in adults. This project addresses the relationship between diminished central serotonergic function in older adolescents (aged 16-19) and the diagnosis and severity of Alcohol Use Disorders, Conduct Disorder, impulsivity and aggressivity, suicidal, and violent behaviors. Serotonergic function is assessed through pharmacologic challenge with dl-fenfluramine (1 mg/kg) and the simultaneous measurement of neuroendocrine responses through blood sampling of prolactin and cortisol, and prefrontal cortical activation responses through fMRI techniques. Dynamic contrast fMRI study of hemodynamic responses in prefrontal cortex during activation with fenfluramine addresses the serotonergic responsiveness of an area intimately involved in self-regulation of impulse, affect, and behavior, while morphometric study by high resolution MRI may reveal structural differences. Eighty adolescents, half with Alcohol Use Disorders and half without will be studied in PAARC Years 06 and 07, with one and three year follow-ups to determine whether neuroendocrine and prefrontal cortical activation response variables predict adverse psychosocial outcomes. Adverse outcomes associated with these psychobiologic variables include: progression of severity of Alcohol Use Disorder, development of adult criteria for ASPD, affective disorders, suicidal, and violent behavior. This study will contribute to our understanding of the psychobiology of adolescent Alcohol Use Disorders and the identification of biologic risk factors that may predict long term adverse psychosocial consequences.