PATHOGENESIS OF FUNCTIONAL HYPOTHALAMIC AMENORRHEA PART II

功能性下丘脑性闭经的发病机制第二部分

• 批准号: 6304716
• 负责人: Sarah L. Berga
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6304716
• 关键词: amenorrhea; attitude; behavior disorders; clinical research; cognitive behavior therapy; female; human subject; pathologic process; psychological stressor; psychophysiology; social psychology; women's health

This proposal is a competing renewal in response to PA-91-100, Special Issues Women's Mental Health Over the Life Cycle. FHA is the most common form of anovulation and data obtained through current investigation implicate dysfunctional attitudes, psychosocial stress and associated behaviors in the genesis of hypothalamic secretory alterations characteristic of FHA. We hypothesize that cognitive behavior therapy (CBT) aimed at improving attitudes and correcting problematic behaviors will reverse FHA and restore ovulation. However, as not all women will respond to CBT, we propose to continue defining the neurobiological mechanism underlying the synergism between psychogenic and metabolic stress with the goal of identifying pharmacologic interventions.

该提案是针对 PA-91-100“女性生命周期中的心理健康特殊问题”的竞争性更新。 FHA 是最常见的无排卵形式，通过目前的调查获得的数据表明，功能失调的态度、社会心理压力和相关行为是 FHA 下丘脑分泌改变特征的发生过程。我们假设旨在改善态度和纠正问题行为的认知行为疗法 (CBT) 将逆转 FHA 并恢复排卵。 然而，由于并非所有女性都会对 CBT 做出反应，我们建议继续定义心因性应激和代谢性应激之间协同作用的神经生物学机制，以期确定药物干预措施。